Oyanagi Takeshi, Sada Yukiyoshi, Sasaki Yosuke, Sone Masakatsu, Tanaka Yasushi
Diabetes Center, Yokohama General Hospital, Kanagawa 225-0025, Japan.
Metabolism and Endocrinology, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
Endocr J. 2023 Sep 28;70(9):925-932. doi: 10.1507/endocrj.EJ23-0022. Epub 2023 Jun 30.
The age-dependent decrease in muscle mass and function is known as sarcopenia. The risk of sarcopenia is higher in patients with diabetes, and assessment of muscle mass and function is especially important in patients with diabetes. Recent reports suggest that the phase angle (PhA), which is obtained from bioelectrical impedance analysis (BIA), may be a good marker of not only muscle mass but also muscle function in healthy people. However, the clinical significance of PhA in patients with diabetes has not been fully investigated. Therefore, we evaluated the association of PhA with muscle mass, muscle strength, and physical performance in 159 patients with type 2 diabetes (male 102; female 57) aged 40 to 89 years. We measured PhA and appendicular skeletal muscle index (SMI) by BIA and handgrip and leg extension strength and performed the Short Physical Performance Battery (SPPB). In a simple correlation analysis, both right and left PhA correlated with SMI, handgrip and leg extension strength, and SPPB score, and in multiple regression analysis, PhA on each side correlated with SMI and ipsilateral handgrip strength. These data suggest that PhA may be a useful marker of muscle mass, muscle strength, and physical performance in patients with type 2 diabetes. A large-scale prospective study should be performed to confirm the results and clarify the clinical usefulness of PhA in patients with diabetes.
肌肉质量和功能随年龄增长而下降的现象被称为肌肉减少症。糖尿病患者发生肌肉减少症的风险更高，因此评估糖尿病患者的肌肉质量和功能尤为重要。最近的报告表明，通过生物电阻抗分析（BIA）获得的相位角（PhA）可能不仅是健康人群肌肉质量的良好指标，也是肌肉功能的良好指标。然而，PhA在糖尿病患者中的临床意义尚未得到充分研究。因此，我们评估了159例年龄在40至89岁之间的2型糖尿病患者（男性102例；女性57例）的PhA与肌肉质量、肌肉力量和身体表现之间的关联。我们通过BIA测量了PhA和四肢骨骼肌指数（SMI），以及握力和腿部伸展力量，并进行了简短身体机能测试（SPPB）。在简单相关性分析中，左右两侧的PhA均与SMI、握力和腿部伸展力量以及SPPB评分相关，在多元回归分析中，每侧的PhA均与SMI和同侧握力相关。这些数据表明，PhA可能是2型糖尿病患者肌肉质量、肌肉力量和身体表现的有用指标。应进行大规模前瞻性研究以证实结果并阐明PhA在糖尿病患者中的临床实用性。
