血清瘦素水平与 2 型糖尿病患者的动脉僵硬度呈正相关。
Serum Leptin Level is Positively Correlated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus.
机构信息
Division of Nephrology, Department of Medicine, Hualien Armed Forces General Hospital, 97144 Hualien, Taiwan.
Institute of Medical Sciences, Tzu Chi University, 97144 Hualien, Taiwan.
出版信息
Front Biosci (Landmark Ed). 2023 Jun 29;28(6):128. doi: 10.31083/j.fbl2806128.
BACKGROUND
The global number of people living with diabetes mellitus (DM) continues to grow. Obesity, smoking, hypercholesterolemia, and hypertension are independently correlated with the risk of cardiovascular disease (CVD) in diabetic patients regardless of differences in race or ethnicity. We aimed to investigate the relationship between serum leptin levels and aortic stiffness in patients with type 2 DM to identify cardiovascular risk at the early stage.
METHODS
A total of 128 diabetic patients were enrolled after screening for eligibility at a medical center in Eastern Taiwan. Aortic stiffness was defined as having a carotid-femoral pulse wave velocity (cfPWV) of >10 m/s using applanation tonometry. Fasting serum levels of leptin and other associated biomarkers were determined by enzyme immunoassay or biochemical analyses.
RESULTS
Forty-six diabetic patients with a cfPWV of >10 m/s were included in the aortic stiffness group. Compared with the control group (n = 82), our aortic stiffness group was significantly older ( = 0.019) and had higher body fat mass ( = 0.002), systolic blood pressure (SBP) ( < 0.001), serum triglyceride ( = 0.02), and serum leptin ( < 0.001). Aortic stiffness was also associated with insulin resistance ( = 0.026) and poorer blood sugar control (higher fasting glucose ( = 0.044) and glycated hemoglobin (HbA1c) ( = 0.049)). In the multivariable linear regression analyses examining the correlations between aortic stiffness and clinical variables, we found that age (β = 0.291; < 0.001), SBP (β = 0.176; = 0.033), logarithmically transformed urinary albumin-creatinine ratio (β = 0.256; = 0.002), and serum leptin levels (β = 0.244; = 0.002) were independently associated with cfPWV values. The analyses showed that only leptin was correlated with a higher probability of aortic stiffness (odds ratio: 1.055, 95% confidence interval: 1.005-1.107, = 0.031).
CONCLUSIONS
The results suggested that serum leptin is positively associated with aortic stiffness in patients with type 2 DM.
背景
全球范围内，糖尿病患者的数量仍在不断增加。肥胖、吸烟、高胆固醇血症和高血压与糖尿病患者的心血管疾病（CVD）风险独立相关，无论种族或民族的差异如何。我们旨在研究 2 型糖尿病患者血清瘦素水平与主动脉僵硬之间的关系，以在早期识别心血管风险。
方法
在台湾东部的一家医学中心进行资格筛选后，共纳入了 128 例糖尿病患者。通过平板压力测量法，将颈动脉-股动脉脉搏波速度（cfPWV）>10m/s 的患者定义为存在主动脉僵硬。通过酶免疫测定或生化分析测定空腹血清瘦素和其他相关生物标志物的水平。
结果
纳入了 46 例 cfPWV>10m/s 的糖尿病患者作为主动脉僵硬组。与对照组（n=82）相比，我们的主动脉僵硬组年龄明显较大（=0.019），体脂肪量较高（=0.002），收缩压（SBP）较高（<0.001），血清甘油三酯较高（=0.02），血清瘦素水平较高（<0.001）。主动脉僵硬还与胰岛素抵抗（=0.026）和血糖控制较差有关（空腹血糖较高（=0.044）和糖化血红蛋白（HbA1c）较高（=0.049））。在多变量线性回归分析中，我们发现，年龄（β=0.291；<0.001）、SBP（β=0.176；=0.033）、对数转化的尿白蛋白/肌酐比值（β=0.256；=0.002）和血清瘦素水平（β=0.244；=0.002）与 cfPWV 值独立相关。分析表明，只有瘦素与主动脉僵硬的发生具有相关性（比值比：1.055，95%置信区间：1.005-1.107，=0.031）。
结论
结果表明，血清瘦素与 2 型糖尿病患者的主动脉僵硬呈正相关。
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