Huang Sin-Yi, Wu Du-An, Tsai Jen-Pi, Hsu Bang-Gee
Department of General Practice, Far Eastern Memorial Hospital, New Taipei City 22016, Taiwan.
School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan.
Int J Environ Res Public Health. 2021 Mar 26;18(7):3434. doi: 10.3390/ijerph18073434.
Aortic stiffness (AS), assessed using carotid-femoral pulse wave velocity (cfPWV), is associated with cardiovascular disease in type 2 diabetes mellitus (T2DM). The relationship between serum fibroblast growth factor 21 (FGF-21) and AS in T2DM patients was evaluated. Fasting serum FGF-21 levels of 130 T2DM patients were measured using an enzyme immunoassay kit. A validated tonometry system was used to measure cfPWV (>10 m/s indicated AS). Of these T2DM patients, 34.6% were defined as the AS group. T2DM patients with AS were older; exhibited higher systolic blood pressure, diastolic blood pressure, and body fat mass; higher triglyceride, fasting glucose, glycosylated hemoglobin, and creatinine levels; higher urine albumin-to-creatinine ratios and serum FGF-21 levels; and lower estimated glomerular filtration rates. The FGF-21 level (odds ratio = 1.005, 95% confidence interval: 1.002-1.009, = 0.002) as well as systolic blood pressure was an independent predictor of AS and positively correlated to cfPWV values (β = 0.369, < 0.001) in T2DM patients. For T2DM patients, serum FGF-21 level could be a predictor for AS.
使用颈股脉搏波速度（cfPWV）评估的主动脉僵硬度（AS）与2型糖尿病（T2DM）患者的心血管疾病相关。评估了T2DM患者血清成纤维细胞生长因子21（FGF-21）与AS之间的关系。使用酶免疫分析试剂盒测量了130例T2DM患者的空腹血清FGF-21水平。使用经过验证的眼压测量系统测量cfPWV（>10 m/s表示AS）。在这些T2DM患者中，34.6%被定义为AS组。患有AS的T2DM患者年龄更大；收缩压、舒张压和体脂质量更高；甘油三酯、空腹血糖、糖化血红蛋白和肌酐水平更高；尿白蛋白与肌酐比值和血清FGF-21水平更高；而估计肾小球滤过率更低。FGF-21水平（比值比=1.005，95%置信区间：1.002-1.009，P=0.002）以及收缩压是T2DM患者AS的独立预测因素，且与cfPWV值呈正相关（β=0.369，P<0.001）。对于T2DM患者，血清FGF-21水平可能是AS的一个预测指标。
