NHS England, England, UK.
Newborn Hearing Screening Programme, NHS England, England, UK.
Int J Audiol. 2024 Aug;63(8):596-603. doi: 10.1080/14992027.2023.2227763. Epub 2023 Jul 3.
To assess the utility of targeted surveillance for the identification of moderate to profound PCHI in babies who pass newborn hearing screening in England and have risk factors.
Retrospective analysis.
A total of 3,957,891 children born 01/04/2012-31/03/2018 in England.
A total of 7148 PCHI cases were identified (1.81 per 1,000 babies). 6,707 followed an immediate referral from the screen (1 per 16 referrals), 51 followed targeted surveillance referral (1 per 540 referrals) and 390 without a referral. Audiology uptake was higher following an immediate referral (96.7% overall, 77.2% within NHSP-defined timescales) than following targeted surveillance (63.8% overall, 51.1% within 52 weeks of birth). The screening was 94.5% sensitive overall, with similar sensitivities for each of the risk factors. General linearised logistic regression models identified syndrome as the risk factor with the highest odds ratio (14.08 for all babies, 22.19 for babies without immediate referral). Close family history of hearing loss was the next highest (10.93 for all babies, 12.29 for babies without immediate referral).
The evidence for a targeted surveillance programme, based on risk factors, for babies in England who pass the newborn screen is not strong.
评估针对有风险因素且通过新生儿听力筛查的婴儿进行目标性监测以识别中重度永久性单侧感觉神经性听力损失(PCHI)的效用。
回顾性分析。
2012 年 4 月 1 日至 2018 年 3 月 31 日期间在英格兰出生的 3957891 名儿童。
共发现 7148 例 PCHI 病例(每千名婴儿中有 1.81 例)。6707 例为听力筛查后直接转诊(每转诊 16 例中有 1 例),51 例为目标性监测转诊(每转诊 540 例中有 1 例),390 例未转诊。听力测试的接受率在直接转诊后更高(总体为 96.7%,在 NHSP 定义的时间范围内为 77.2%),而在目标性监测后更低(总体为 63.8%,在出生后 52 周内为 51.1%)。该筛查总体敏感度为 94.5%,各风险因素的敏感度相似。广义线性逻辑回归模型确定综合征是风险因素中比值比最高的因素(所有婴儿为 14.08,无直接转诊婴儿为 22.19)。家族中存在听力损失史是第二高的风险因素(所有婴儿为 10.93,无直接转诊婴儿为 12.29)。
针对通过新生儿听力筛查的英格兰婴儿进行基于风险因素的目标性监测方案的证据不足。