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直接口服抗凝剂治疗的髋部骨折患者围手术期结局及管理的综述

Review of perioperative outcomes and management of hip fracture patients on direct oral anticoagulants.

作者信息

Wall Pelle V, Mitchell Brendon C, Ta Canhnghi N, Kent William T

机构信息

University of California San Diego School of Medicine, Gilman Drive, La Jolla, California, United States of America.

Department of Orthopaedic Surgery, University of California San Diego, West Arbor Drive, California, United States of America.

出版信息

EFORT Open Rev. 2023 Jul 3;8(7):561-571. doi: 10.1530/EOR-22-0060.

Abstract

Anticoagulation use is common in elderly patients presenting with hip fractures and has been shown to delay time to surgery (TTS). Delays in operative treatment have been associated with worse outcomes in hip fracture patients. Direct oral anticoagulants (DOACs) comprise a steadily increasing proportion of all oral anticoagulation. Currently, no clear guidelines exist for perioperative management of hip fracture patients taking DOACs. DOAC use is associated with increased TTS, with delays frequently greater than 48 h from hospital presentation. Increased mortality has not been widely demonstrated in DOAC patients, despite increased TTS. Timing of surgery was not found to be associated with increased risk of transfusion or bleeding. Early surgery appears to be safe in patients taking DOACs presenting with a hip fracture, but is not currently widely accepted due to factors such as site-specific anesthesiologic protocols that periodically delay surgery. Direct oral anticoagulant use should not routinely delay surgical treatment in hip fracture patients. Surgical strategies to limit blood loss should be considered and include efficient surgical fixation, topical application of hemostatic agents, and the use of intra-operative cell salvage. Anesthesiologic strategies have utility in minimizing risk and a collaborative effort to minimize blood loss should be undertaken by the surgeon and anesthesiologist. Anesthesia team interventions include considerations regarding positioning, regional anesthesia, permissive hypotension, avoidance of hypothermia, judicious administration of blood products, and the use of systemic hemostatic agents.

摘要

抗凝治疗在老年髋部骨折患者中很常见,且已被证明会延迟手术时间(TTS)。手术治疗延迟与髋部骨折患者预后较差有关。直接口服抗凝剂(DOACs)在所有口服抗凝药物中所占比例稳步增加。目前,对于服用DOACs的髋部骨折患者围手术期管理尚无明确指南。使用DOACs与手术时间延长相关,从入院起延误时间常常超过48小时。尽管手术时间延长,但DOACs使用者死亡率增加的情况尚未得到广泛证实。未发现手术时机与输血或出血风险增加有关。对于髋部骨折且服用DOACs的患者,早期手术似乎是安全的,但由于特定部位麻醉方案等因素会定期延迟手术,目前尚未被广泛接受。在髋部骨折患者中,不应常规因使用直接口服抗凝剂而延迟手术治疗。应考虑采取限制失血的手术策略,包括有效的手术固定、局部应用止血剂以及术中使用细胞回收技术。麻醉策略在降低风险方面具有作用,外科医生和麻醉医生应共同努力将失血降至最低。麻醉团队的干预措施包括对体位、区域麻醉、允许性低血压、避免体温过低、谨慎输注血液制品以及使用全身性止血剂等方面的考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de5/10321051/2bcb25f4c9d6/EOR-22-0060fig1.jpg

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