Shanxi Medical University, Taiyuan City, 030001, Shanxi Province, China.
Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Shanxi Medical University, No. 85, Jiefang South Road, Yingze District, Taiyuan City, 030001, Shanxi Province, China.
Appl Biochem Biotechnol. 2024 Mar;196(3):1376-1385. doi: 10.1007/s12010-023-04593-9. Epub 2023 Jul 3.
Vascular causes are most commonly associated with sudden sensorineural hearing loss (SSHL). This study was performed to determine the relationship between serum endothelin-1 (ET-1), high-density lipoprotein cholesterol (HDL-C), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels, and the degree of hearing loss in patients with SSHL. Firstly, 60 SSHL patients were admitted to The First Hospital of Shanxi Medical University. In the same period, 60 healthy subjects matching the age and gender of SSHL patients were selected as the control group. Then, serum levels of ET-1, HDL-C, and sVCAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). Next, the relationship between serum levels of ET-1, HDL-C, and sVCAM-1 with clinicopathological factors and their diagnostic and prognostic values were analyzed and evaluated. Serum ET-1 and sVCAM-1 were increased, and HDL-C was decreased in patients with SSHL. Serum ET-1 and sVCAM-1 were higher and HDL-C was lower in patients aged ≥ 45 years, or severe hearing loss patients (P < 0.05). ROC analysis determined that ET-1 (AUC = 0.839), HDL-C (AUC = 0.830), and sVCAM-1 (AUC = 0.865) had excellent diagnostic values. In addition, patients with low levels of ET-1 and sVCAM-1 and high levels of HDL-C had better hearing prognosis (P < 0.05). Abnormal serum ET-1, HDL-C, and sVCAM-1 in patients with SSHL are closely related to age, and degree of hearing loss, and perform diagnostic and prognostic values.
血管原因通常与突发性聋（SSHL）有关。本研究旨在确定血清内皮素-1（ET-1）、高密度脂蛋白胆固醇（HDL-C）、可溶性血管细胞黏附分子-1（sVCAM-1）水平与 SSHL 患者听力损失程度的关系。首先，山西医科大学第一医院收治了 60 例 SSHL 患者。同期选择年龄、性别与 SSHL 患者匹配的 60 例健康受试者作为对照组。然后，采用酶联免疫吸附试验（ELISA）测定血清 ET-1、HDL-C 和 sVCAM-1 水平。接着，分析并评价血清 ET-1、HDL-C 和 sVCAM-1 水平与临床病理因素的关系及其诊断和预后价值。SSHL 患者的血清 ET-1 和 sVCAM-1 升高，HDL-C 降低。年龄≥45 岁或重度听力损失患者的血清 ET-1 和 sVCAM-1 更高，HDL-C 更低（P<0.05）。ROC 分析确定 ET-1（AUC=0.839）、HDL-C（AUC=0.830）和 sVCAM-1（AUC=0.865）具有良好的诊断价值。此外，ET-1 和 sVCAM-1 水平低、HDL-C 水平高的患者听力预后更好（P<0.05）。SSHL 患者血清 ET-1、HDL-C 和 sVCAM-1 异常与年龄和听力损失程度密切相关，具有诊断和预后价值。
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