Liu Xinghong, Xu Xianpeng, Lei Qiulian, Jin Xiaohua, Deng Xinxing, Xie Hui
Department of Otorhinolaryngology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Neurol. 2024 Aug 13;15:1453055. doi: 10.3389/fneur.2024.1453055. eCollection 2024.
Our objective was to explore the efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss by conducting an umbrella review of all existing evidence.
We conducted an umbrella review, searching for related articles in the PubMed, Web of Science, Embase, and Scopus databases. The search period covered from the inception of each database until April 2024. We extracted authors, country of publication, time of publication, number of included studies and participants, interventions, summary of results, -values, , relative risk (95% CI), and outcome measures. The methodological quality, evidence quality, and overlap rate of the included articles were assessed using AMSTAR 2, GRADE, and OVErviews (GROOVE).
Methodological quality was assessed using AMSTAR 2. Of the nine included articles, two were assessed as "high," three as "moderate," two as "low," and the remaining two as "very low." The quality of evidence was assessed using the GRADE system. It was found that the quality of evidence in most of the studies was unsatisfactory. It was found that there was a slight overlap among the included articles. Six studies reported positive results (OR 1.37; 95% CI, 1.17-1.61; = 0.04), with high heterogeneity observed ( = 63%). Egger's test indicated bias ( = 0.000101). Three studies reported negative results (MD 1.49; 95% CI, -0.32 to 3.29; = 0.43; = 0%), with no significant bias detected ( = 0.106) according to Egger's test.
HBO therapy is shown to be an effective treatment for SSNHL with fewer side effects. However, the methodological quality and evidence of the systematic reviews and meta-analysis included in this study were generally low. Therefore, more high-quality, large-scale, multi-center randomized controlled trials are needed in the future to verify the efficacy of HBO therapy for SSNHL.
https://www.crd.york.ac.uk/prospero, identifier [CRD42024523651].
我们的目的是通过对所有现有证据进行汇总分析，探讨高压氧治疗突发性感音神经性听力损失的疗效。
我们进行了一项汇总分析，在PubMed、科学网、Embase和Scopus数据库中检索相关文章。检索期涵盖每个数据库建库至2024年4月。我们提取了作者、发表国家、发表时间、纳入研究和参与者的数量、干预措施、结果摘要、P值、I²、相对风险（95%置信区间）和结局指标。使用AMSTAR 2、GRADE和OVErviews（GROOVE）评估纳入文章的方法学质量、证据质量和重叠率。
使用AMSTAR 2评估方法学质量。纳入的9篇文章中，2篇被评估为“高”，3篇为“中”，2篇为“低”，其余2篇为“极低”。使用GRADE系统评估证据质量。发现大多数研究的证据质量不令人满意。发现纳入的文章之间存在轻微重叠。6项研究报告了阳性结果（OR = 1.37；95% CI，1.17 - 1.61；P = 0.04），观察到高度异质性（I² = 63%）。Egger检验表明存在偏倚（P = 0.000101）。3项研究报告了阴性结果（MD = 1.49；95% CI， - 0.32至3.29；P = 0.43；I² = 0%），根据Egger检验未检测到显著偏倚（P = 0.106）。
高压氧疗法被证明是治疗突发性感音神经性听力损失的有效方法，副作用较少。然而，本研究中纳入的系统评价和荟萃分析的方法学质量和证据总体较低。因此，未来需要更多高质量、大规模、多中心的随机对照试验来验证高压氧疗法治疗突发性感音神经性听力损失的疗效。
