日本非糖尿病患者体重增加时胰腺体积和胰腺脂肪的纵向变化：基于健康体检数据的分析
Longitudinal changes in pancreatic volume and pancreatic fat with weight gain in Japanese without diabetes: An analysis using health check-up data.
作者信息
Sunouchi Maria, Inaishi Jun, Shimizu-Hirota Ryoko, Saisho Yoshifumi, Hayashi Kaori, Takaishi Hiromasa, Itoh Hiroshi
机构信息
Keio University School of Medicine, Department of Endocrinology, Metabolism and Nephrology, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Keio University School of Medicine, Center for Preventive Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
出版信息
Metabol Open. 2023 Jun 12;19:100250. doi: 10.1016/j.metop.2023.100250. eCollection 2023 Sep.
AIMS/INTRODUCTION: There have been few reports about the longitudinal changes in pancreas volume (PV) or pancreatic steatosis (PS) in response to obesity. In this longitudinal analysis using health check-up data, we explored changes in PV, PS and glucose metabolic indices that occurred after weight gain in Japanese without diabetes.
MATERIALS/METHODS: Clinical data on 37 Japanese subjects with a ≥1 kg/m increase in body mass index between two health check-ups and without diabetes were collected. PV, pancreas attenuation (PA) and splenic attenuation (SA) were evaluated using computed tomography (CT) images. The pancreas area was outlined by hand in multiple images with slice thickness of 2 mm, and the PV was computed by summing these areas. PS was defined as the difference between SA and PA (SA-PA). Medical records were collected, including findings on immunoreactive insulin (IRI), homeostasis model assessment of insulin resistance (HOMA-R) and beta cell function (HOMA-β). Paired -test and Spearman's correlation coefficient were used in the analyses.
RESULTS
The median follow-up period was 21.1 months and the mean BMI was increased from 25.5 ± 3.3 kg/m to 27.0 ± 3.3 kg/m. PV (53.5 ± 15.9 cm vs. 56.2 ± 16.4 cm) and SA-PA (8.7 ± 9.1 HU vs. 13.6 ± 10.9 HU) increased significantly after weight gain (both, P < 0.001). There were significant increases of IRI and HOMA-R with the weight gain (both, P < 0.05), whereas HOMA-β exhibited only a nonsignificant trend of increase (55.4％ (41.5-65.5) vs. 56.8％ (46.2-83.7), P = 0.07).
CONCLUSIONS
Both PV and PS were increased longitudinally with weight gain in Japanese without diabetes.
目的/引言：关于肥胖导致的胰腺体积（PV）或胰腺脂肪变性（PS）的纵向变化的报道较少。在这项使用健康检查数据的纵向分析中，我们探讨了无糖尿病的日本人体重增加后PV、PS和糖代谢指标的变化。
材料/方法：收集了37名日本受试者的临床数据，这些受试者在两次健康检查之间体重指数增加≥1kg/m²且无糖尿病。使用计算机断层扫描（CT）图像评估PV、胰腺衰减（PA）和脾脏衰减（SA）。在多个层厚为2mm的图像上手动勾勒出胰腺区域，并通过将这些区域相加来计算PV。PS定义为SA与PA的差值（SA-PA）。收集病历，包括免疫反应性胰岛素（IRI）、胰岛素抵抗稳态模型评估（HOMA-R）和β细胞功能（HOMA-β）的检查结果。分析中使用配对t检验和Spearman相关系数。
结果
中位随访期为21.1个月，平均体重指数从25.5±3.3kg/m²增加到27.0±3.3kg/m²。体重增加后，PV（53.5±15.9cm³对56.2±16.4cm³）和SA-PA（8.7±9. HU对13.6±10.9HU）显著增加（均P<0.001）。体重增加后，IRI和HOMA-R显著升高（均P<0.05），而HOMA-β仅呈现不显著的升高趋势（55.4％（41.5-65.5）对56.8％（46.2-83.7），P=0.07）。
结论
在无糖尿病的日本人中，PV和PS均随体重增加而纵向增加。
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