一个SLC31A1-MEK-DNMT1-miR-124反馈环促进胰腺癌进展。 - Suppr

A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression.

作者信息

Jin Jing, Ma Mingjun, Yan Bingru, Qiu Botao, Lu Shounan, Yang Lin, Nie Yuzhe, Tai Sheng, Yu Ze, Teng Chun-Bo

机构信息

College of Life Science, Northeast Forestry University, Harbin, Heilongjiang 150040, China.

Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150007, China.

出版信息

Genes Dis. 2022 Jun 11;10(3):654-656. doi: 10.1016/j.gendis.2022.05.033. eCollection 2023 May.

DOI:10.1016/j.gendis.2022.05.033

PMID:37396508

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308097/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a053/10308097/3fd65cdaa907/gr1.jpg

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A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression.

作者信息

Jin Jing, Ma Mingjun, Yan Bingru, Qiu Botao, Lu Shounan, Yang Lin, Nie Yuzhe, Tai Sheng, Yu Ze, Teng Chun-Bo

机构信息

College of Life Science, Northeast Forestry University, Harbin, Heilongjiang 150040, China.

Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150007, China.

出版信息

Genes Dis. 2022 Jun 11;10(3):654-656. doi: 10.1016/j.gendis.2022.05.033. eCollection 2023 May.

DOI:10.1016/j.gendis.2022.05.033

PMID:37396508

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308097/

Abstract

摘要

相似文献

A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression.

Genes Dis. 2022 Jun 11;10(3):654-656. doi: 10.1016/j.gendis.2022.05.033. eCollection 2023 May.

DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.

Exp Cell Res. 2016 Aug 15;346(2):176-87. doi: 10.1016/j.yexcr.2016.07.023. Epub 2016 Jul 28.

A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells.

Cell Physiol Biochem. 2017;41(3):973-986. doi: 10.1159/000460618. Epub 2017 Feb 21.

MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism.

Carcinogenesis. 2013 Feb;34(2):446-53. doi: 10.1093/carcin/bgs343. Epub 2012 Nov 3.

miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer.

Oncol Res. 2022 Jan 31;28(9):885-897. doi: 10.3727/096504021X16274672547967. Epub 2021 Jul 28.

miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.

Cell Death Dis. 2016 Dec 1;7(12):e2503. doi: 10.1038/cddis.2016.373.

miR-148a, miR-152 and miR-200b promote prostate cancer metastasis by targeting DNMT1 and PTEN expression.

Oncol Lett. 2021 Nov;22(5):805. doi: 10.3892/ol.2021.13066. Epub 2021 Sep 23.

A ceRNA network-mediated over-expression of cuproptosis-related gene SLC31A1 correlates with poor prognosis and positive immune infiltration in breast cancer.

Front Med (Lausanne). 2023 May 18;10:1194046. doi: 10.3389/fmed.2023.1194046. eCollection 2023.

The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.

Cancer Invest. 2015;33(7):267-75. doi: 10.3109/07357907.2015.1025794. Epub 2015 May 7.

DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.

J Biol Chem. 2019 Nov 29;294(48):18122-18130. doi: 10.1074/jbc.RA119.010144. Epub 2019 Oct 18.

引用本文的文献

Plasma IgG and IgM autoantibodies to COPT1 as potential biomarkers for detection of non-small cell lung cancer.

Front Immunol. 2025 Apr 11;16:1455095. doi: 10.3389/fimmu.2025.1455095. eCollection 2025.

Cuproptosis in cancer: biological implications and therapeutic opportunities.

Cell Mol Biol Lett. 2024 Jun 25;29(1):91. doi: 10.1186/s11658-024-00608-3.

本文引用的文献

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Nat Med. 2019 Apr;25(4):620-627. doi: 10.1038/s41591-019-0367-9. Epub 2019 Mar 4.

Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death.

Cell Prolif. 2019 Mar;52(2):e12568. doi: 10.1111/cpr.12568. Epub 2019 Jan 31.

Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway.

Oncogene. 2018 Jun;37(25):3440-3455. doi: 10.1038/s41388-018-0222-3. Epub 2018 Mar 21.

Copper is required for oncogenic BRAF signalling and tumorigenesis.

Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9.

Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1.

Oncogene. 2014 Jan 23;33(4):514-24. doi: 10.1038/onc.2012.598. Epub 2013 Jan 21.

A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression.

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A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression.

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