Kataoka Y, Gomita Y, Fukuda T, Eto K, Araki Y
Acta Med Okayama. 1986 Jun;40(3):121-6. doi: 10.18926/AMO/31937.
Methamphetamine (MA) toxicity in aggregated mice was studied by varying the number of mice and the proportion of MA treated mice kept in the same confined space. The lethality was measured 24 h after intraperitoneal injections of MA at doses ranging from 10 to 100 mg/kg. MA lethality, over a wide dose range (15 to 50 mg/kg), was higher in aggregated mice than in those maintained in isolation. The greater the proportion of MA-treated mice in aggregation was, the higher the MA lethality was. In aggregations of 10 mice, MA was lethal at lower doses than in aggregations of 5 mice. These results indicate that the lethality of MA is influenced by confinement and aggregation.
通过改变小鼠数量以及在同一密闭空间中接受甲基苯丙胺（MA）处理的小鼠比例，研究了聚集状态下小鼠的MA毒性。在腹腔注射剂量为10至100mg/kg的MA后24小时测量致死率。在较宽的剂量范围（15至50mg/kg）内，聚集状态下的小鼠MA致死率高于单独饲养的小鼠。聚集状态下接受MA处理的小鼠比例越高，MA致死率越高。在10只小鼠的聚集中，MA在比5只小鼠聚集时更低的剂量下就具有致死性。这些结果表明，MA的致死率受密闭环境和聚集状态的影响。
