空气污染、细胞内外水分布与阻塞性睡眠呼吸暂停表现之间的关联。

Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations.

机构信息

Department of Civil and Environmental Engineering, Imperial College London, London, United Kingdom.

Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.

出版信息

Front Public Health. 2023 Jun 15;11:1175203. doi: 10.3389/fpubh.2023.1175203. eCollection 2023.

DOI:10.3389/fpubh.2023.1175203

PMID:37397706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10310528/

Abstract

BACKGROUND

Exposure to air pollution may be a risk factor for obstructive sleep apnea (OSA) because air pollution may alter body water distribution and aggravate OSA manifestations.

OBJECTIVES

This study aimed to investigate the mediating effects of air pollution on the exacerbation of OSA severity through body water distribution.

METHODS

This retrospective study analyzed body composition and polysomnographic data collected from a sleep center in Northern Taiwan. Air pollution exposure was estimated using an adjusted nearest method, registered residential addresses, and data from the databases of government air quality motioning stations. Next, regression models were employed to determine the associations between estimated air pollution exposure levels (exposure for 1, 3, 6, and 12 months), OSA manifestations (sleep-disordered breathing indices and respiratory event duration), and body fluid parameters (total body water and body water distribution). The association between air pollution and OSA risk was determined.

RESULTS

Significant associations between OSA manifestations and short-term (1 month) exposure to PM and PM were identified. Similarly, significant associations were identified among total body water and body water distribution (intracellular-to-extracellular body water distribution), short-term (1 month) exposure to PM and PM, and medium-term (3 months) exposure to PM. Body water distribution might be a mediator that aggravates OSA manifestations, and short-term exposure to PM and PM may be a risk factor for OSA.

CONCLUSION

Because exposure to PM and PM may be a risk factor for OSA that exacerbates OSA manifestations and exposure to particulate pollutants may affect OSA manifestations or alter body water distribution to affect OSA manifestations, mitigating exposure to particulate pollutants may improve OSA manifestations and reduce the risk of OSA. Furthermore, this study elucidated the potential mechanisms underlying the relationship between air pollution, body fluid parameters, and OSA severity.

摘要

背景

暴露于空气污染可能是阻塞性睡眠呼吸暂停（OSA）的一个风险因素，因为空气污染可能改变身体水分分布并加重 OSA 表现。

目的

本研究旨在通过身体水分分布，研究空气污染对 OSA 严重程度恶化的中介作用。

方法

本回顾性研究分析了来自台湾北部睡眠中心的身体成分和多导睡眠图数据。使用调整后的最近邻方法、注册的居住地址以及政府空气质量运动站数据库中的数据来估计空气污染暴露。然后，回归模型用于确定估计的空气污染暴露水平（暴露 1、3、6 和 12 个月）与 OSA 表现（睡眠障碍呼吸指数和呼吸事件持续时间）以及体液参数（总体水和身体水分分布）之间的关联。确定了空气污染与 OSA 风险之间的关联。

结果

OSA 表现与 PM 和 PM 的短期（1 个月）暴露之间存在显著关联。同样，在总身体水和身体水分分布（细胞内到细胞外的身体水分分布）、PM 和 PM 的短期（1 个月）暴露以及 PM 的中期（3 个月）暴露之间也存在显著关联。身体水分分布可能是加重 OSA 表现的中介，PM 和 PM 的短期暴露可能是 OSA 的一个风险因素。

结论

由于 PM 和 PM 的暴露可能是加重 OSA 表现的 OSA 风险因素，并且颗粒性污染物的暴露可能会影响 OSA 表现或改变身体水分分布从而影响 OSA 表现，因此减轻颗粒性污染物的暴露可能会改善 OSA 表现并降低 OSA 风险。此外，本研究阐明了空气污染、体液参数和 OSA 严重程度之间关系的潜在机制。