The University of Melbourne, School of Population & Global Health, 207, Bouverie Street, Carlton, VIC 3052, Australia.
The University of Melbourne, School of Population & Global Health, Centre for Epidemiology and Biostatistics, Allergy and Lung Health, 207, Bouverie Street, Carlton, VIC 3052, Australia.
Sleep Med Rev. 2020 Dec;54:101360. doi: 10.1016/j.smrv.2020.101360. Epub 2020 Jul 11.
Recent evidence suggests that air pollution exposure may be a contributing risk factor for obstructive sleep apnea (OSA), however, current evidence is conflicting. This systematic review aims to determine the association between air pollution and OSA in the general population, and examine for potential effect modification by seasonality, temperature and humidity. Five full-text articles were included in the review out of 905 articles found by systematically searching PubMed, Embase and Scopus databases. The included studies were limited to OSA in adults that were conducted in middle to high-income countries. The results highlight heterogeneity in the diagnostic criteria for OSA and method used to assess air pollution exposure. There is some evidence to support a relationship between air pollution exposure and OSA. However, the duration of exposure to different air pollutants including particulate matter (PM and PM) and nitric oxides (NO) in relation to OSA varied across different seasons, temperatures, and countries. This variability of the pollutants across studies warrants a more robust study design using time-series analysis with multiple follow-ups to strengthen the evidence for this relationship before considering its implications.
最近的证据表明，空气污染暴露可能是阻塞性睡眠呼吸暂停（OSA）的一个致病因素，但目前的证据存在矛盾。本系统评价旨在确定一般人群中空气污染与 OSA 之间的关联，并研究季节性、温度和湿度对其潜在的影响修饰作用。在系统搜索 PubMed、Embase 和 Scopus 数据库后，共找到了 905 篇文章，其中有 5 篇全文文章被纳入本综述。纳入的研究仅限于在中高收入国家进行的成人 OSA 研究。研究结果突出了 OSA 的诊断标准和评估空气污染暴露方法的异质性。有一些证据支持空气污染暴露与 OSA 之间存在关系。然而，暴露于不同空气污染物（包括颗粒物（PM 和 PM）和氮氧化物（NO））与 OSA 的关系在不同季节、温度和国家之间存在差异。不同研究中污染物的这种变异性需要更强大的研究设计，使用时间序列分析和多次随访，以在考虑其影响之前加强这一关系的证据。
