He Yang-Huan, Pan Jia-Xing, Xu Lei-Ming, Gu Ting, Chen Yuan-Wen
Department of Gastroenterology and Department of Geriatrics, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
World J Hepatol. 2023 Jun 27;15(6):725-740. doi: 10.4254/wjh.v15.i6.725.
Non-alcoholic fatty liver disease (NAFLD) or metabolic (dysfunction)-associated fatty liver disease is the leading cause of chronic liver diseases defined as a disease spectrum comprising hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatic carcinoma. NASH, characterized by hepatocyte injury, steatosis, inflammation, and fibrosis, is associated with NAFLD prognosis. Ductular reaction (DR) is a common compensatory reaction associated with liver injury, which involves the hepatic progenitor cells (HPCs), hepatic stellate cells, myofibroblasts, inflammatory cells (such as macrophages), and their secreted substances. Recently, several studies have shown that the extent of DR parallels the stage of NASH and fibrosis. This review summarizes previous research on the correlation between DR and NASH, the potential interplay mechanism driving HPC differentiation, and NASH progression.
非酒精性脂肪性肝病（NAFLD）或代谢（功能障碍）相关脂肪性肝病是慢性肝病的主要原因，其被定义为一种疾病谱，包括肝脂肪变性、非酒精性脂肪性肝炎（NASH）、肝纤维化、肝硬化和肝癌。NASH的特征为肝细胞损伤、脂肪变性、炎症和纤维化，与NAFLD的预后相关。胆管反应（DR）是一种与肝损伤相关的常见代偿反应，涉及肝祖细胞（HPCs）、肝星状细胞、肌成纤维细胞、炎性细胞（如巨噬细胞）及其分泌物质。最近，多项研究表明DR的程度与NASH和纤维化的阶段平行。本综述总结了以往关于DR与NASH之间的相关性、驱动HPC分化的潜在相互作用机制以及NASH进展的研究。
