Mori Y, Masuda F, Nakata J, Onishi T, Suzuki M, Iizuka N, Machida T, Kurihara S, Konishi M, Sakai T
Hinyokika Kiyo. 1986 Apr;32(4):513-7.
Coagulum pyelolithotomy was carried out on 20 patients from January, 1980 to April 1984. Nephrolithotomy was jointly carried out on 4 of them, but residual stones were observed in 4 cases (20%). No side effect such as hepatitis was observed in any cases. While inferring the cause of residue, experimental study was made on tension, coagulation time and mixing method in respect to coagulum formation. In the experiment on tension, no significant difference was observed when thrombin concentration was changed, but when calcium was added, tension increased 4 fold. As thrombin concentration rose, so shortened the coagulation time. It was inferred that a better coagulum is made available if fibrinogen and thrombin are mixed outside the kidney.
1980年1月至1984年4月，对20例患者实施了凝块肾盂切开取石术。其中4例同时进行了肾切开取石术，但有4例（20%）观察到残留结石。所有病例均未观察到肝炎等副作用。在推断残留原因时，针对凝块形成的张力、凝血时间和混合方法进行了实验研究。在张力实验中，当凝血酶浓度改变时未观察到显著差异，但添加钙后，张力增加了4倍。随着凝血酶浓度升高，凝血时间缩短。据推断，如果纤维蛋白原和凝血酶在肾外混合，可形成更好的凝块。
