International Research Center in Critical Raw Materials-ICCRAM, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain.
Current Address: ITENE Research Center, Industrial Biotechnology Area, C/Albert Einstein 1, 46980, Paterna, Valencia, Spain.
ChemSusChem. 2023 Dec 19;16(24):e202300626. doi: 10.1002/cssc.202300626. Epub 2023 Sep 11.
Viologen-derivatives are the most widely used redox organic molecules for neutral pH negative electrolyte of redox flow batteries. However, the long-established toxicity of the herbicide methyl-viologen raises concern for deployment of viologen-derivatives at large scale in flow batteries. Herein, we demonstrate the radically different cytotoxicity and toxicology of a series of viologen-derivatives in in vitro assays using model organisms representative of human and environmental exposure, namely human lung carcinoma epithelial cell line (A549) and the yeast Saccharomyces cerevisiae. The results show that safe viologen derivatives can be molecularly engineered, representing a promising family of negolyte materials for neutral redox flow batteries.
联吡啶衍生物是最广泛用于氧化还原流电池中性 pH 负电解质的氧化还原有机分子。然而，除草剂百草枯的长期毒性引起了人们对在流电池中大规模使用联吡啶衍生物的关注。在此，我们使用代表人类和环境暴露的模式生物，即人肺癌上皮细胞系（A549）和酵母酿酒酵母，在体外试验中证明了一系列联吡啶衍生物具有截然不同的细胞毒性和毒理学。结果表明，可以通过分子工程设计安全的联吡啶衍生物，这代表了一类用于中性氧化还原流电池的有前途的 negolyte 材料。
