Meyer W, Görgen S, Schlesinger C
Am J Anat. 1986 Jun;176(2):207-19. doi: 10.1002/aja.1001760209.
Epidermal development of fetal porcine skin was studied in fetuses from 41 days of gestation until birth with scanning and electron microscopy techniques as well as histochemical methods, including immunohistochemistry. The porcine fetus develops a relatively thick and solid multilayered cover of epidermal cells, which is not lost before birth. It consists of tightly packed cells of the periderm and the stratum intermedium. The periderm cells are totally filled with filamentous proteins; in the intermediate cells, the filamentous proteins are concentrated in the cell periphery, forming a thick marginal zone. Immunohistochemically, the cytofilaments could be identified as cytokeratins of lower and higher molecular weights. The first thin stratum corneum lamellae are formed below the stratum intermedium at about 80-85 days of gestation.
运用扫描电子显微镜技术、电子显微镜技术以及包括免疫组织化学在内的组织化学方法，对妊娠41天至出生的胎猪皮肤的表皮发育进行了研究。猪胎儿发育出一层相对较厚且坚实的多层表皮细胞覆盖层，在出生前不会脱落。它由紧密排列的周皮细胞和中间层组成。周皮细胞完全充满丝状蛋白质；在中间层细胞中，丝状蛋白质集中在细胞周边，形成一个厚的边缘区。通过免疫组织化学方法，可以鉴定出细胞丝为低分子量和高分子量的细胞角蛋白。在妊娠约80 - 85天时，在中间层下方形成了最初的薄角质层薄片。
