Department of Cardiology, The First People's Hospital of Changde City, Changde 415003, Hunan, China.
The Central Hospital of Hengyang, Hengyang, Hunan 421001, China.
Biomed Pharmacother. 2023 Sep;165:114706. doi: 10.1016/j.biopha.2023.114706. Epub 2023 Jul 1.
Acute myocardial infarction remains the leading cause of death in humans. Timely restoration of blood perfusion to ischemic myocardium remains the most effective strategy in the treatment of acute myocardial infarction, which can significantly reduce morbidity and mortality. However, after restoration of blood flow and reperfusion, myocardial injury will aggravate and induce apoptosis of cardiomyocytes, a process called myocardial ischemia-reperfusion injury. Studies have shown that the loss and death of cardiomyocytes caused by oxidative stress, iron load, increased lipid peroxidation, inflammation and mitochondrial dysfunction, etc., are involved in myocardial ischemia-reperfusion injury. In recent years, with the in-depth research on the pathology of myocardial ischemia-reperfusion injury, people have gradually realized that there is a new form of cell death in the pathological process of myocardial ischemia-reperfusion injury, namely ferroptosis. A number of studies have found that in the myocardial tissue of patients with acute myocardial infarction, there are pathological changes closely related to ferroptosis, such as iron metabolism disorder, lipid peroxidation, and increased reactive oxygen species free radicals. Natural plant products such as resveratrol, baicalin, cyanidin-3-O-glucoside, naringenin, and astragaloside IV can also exert therapeutic effects by correcting the imbalance of these ferroptosis-related factors and expression levels. Combining with our previous studies, this review summarizes the regulatory mechanism of natural plant products intervening ferroptosis in myocardial ischemia-reperfusion injury in recent years, in order to provide reference information for the development of targeted ferroptosis inhibitor drugs for the treatment of cardiovascular diseases.
急性心肌梗死仍然是人类死亡的主要原因。及时恢复缺血心肌的血液灌注仍然是急性心肌梗死治疗中最有效的策略，可显著降低发病率和死亡率。然而，在血流恢复和再灌注后，心肌损伤会加重并诱导心肌细胞凋亡，这一过程称为心肌缺血再灌注损伤。研究表明，氧化应激、铁负荷增加、脂质过氧化、炎症和线粒体功能障碍等引起的心肌细胞丢失和死亡与心肌缺血再灌注损伤有关。近年来，随着对心肌缺血再灌注损伤病理的深入研究，人们逐渐认识到在心肌缺血再灌注损伤的病理过程中存在一种新的细胞死亡形式，即铁死亡。大量研究发现，在急性心肌梗死患者的心肌组织中，存在与铁死亡密切相关的病理变化，如铁代谢紊乱、脂质过氧化和活性氧自由基增加。白藜芦醇、黄芩苷、矢车菊素-3-O-葡萄糖苷、柚皮苷和黄芪甲苷等天然植物产物也可以通过纠正这些与铁死亡相关的因素和表达水平的失衡发挥治疗作用。结合我们以前的研究，本综述总结了近年来天然植物产物干预心肌缺血再灌注损伤中铁死亡的调节机制，以期为治疗心血管疾病的靶向铁死亡抑制剂药物的开发提供参考信息。
