Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan.
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5654-5661. doi: 10.26355/eurrev_202306_32805.
The goal of this study was to look at the patterns of thyroid tumors and how thyroid cancer markers showed up in immunohistochemistry in Northern Saudi Arabia.
This study investigated retrospectively 190 patients who attended with thyroid complaints. About 140 thyroid biopsies were diagnosed in the Department of Pathology at King Salman Hospital, Ha'il, from November 2019 to November 2020.
Out of the 190 patients who attended with thyroid complaints, 140/190 (73.7%) were detected with thyroid lesions (58 malignant and 82 benign). Benign lesions included goiter 49/82 (60%), follicular adenoma 17/82 (21%), Hashimoto's thyroiditis 13/82 (16%), and toxic goiter 3/82 (3%). 5/6 (83.3%) of males with benign lesions had goiters. CK19 was positive in 68.5% of the cases; 71.8% were papillary, 66.7% were follicular, and 100% were undifferentiated carcinomas. Out of the 26/54 (48%) CD56-positive cases, 18/39 (46%) were papillary, 7/12 (58.3%) were follicular, and 3/3 (100%) were undifferentiated carcinomas. Out of the 35/54 (64.8%) Galectin-3-positive cases, 69.2% were papillary, 7/12 (58.3%) were follicular, and 3/3 (100%) were undifferentiated carcinomas.
Thyroid cancer is prevalent in northern Saudi Arabia, with the predominant type being papillary thyroid carcinoma. Most patients are female and younger. The combined use of CK19, CD56, and Galectin-3 tumor markers assists in the accurate differential diagnosis of thyroid neoplasms.
本研究旨在观察沙特阿拉伯北部甲状腺肿瘤的模式以及甲状腺癌标志物在免疫组织化学中的表现。
本研究回顾性调查了 2019 年 11 月至 2020 年 11 月在哈伊勒国王萨勒曼医院病理科就诊的 190 例甲状腺疾病患者。约 140 例甲状腺活检被诊断为甲状腺病变，其中 58 例为恶性，82 例为良性。良性病变包括甲状腺肿 49/82（60%）、滤泡性腺瘤 17/82（21%）、桥本甲状腺炎 13/82（16%）和毒性甲状腺肿 3/82（3%）。5/6（83.3%）名良性病变男性均为甲状腺肿。68.5%的病例 CK19 阳性；71.8%为乳头状，66.7%为滤泡状，100%为未分化癌。26/54（48%）CD56 阳性病例中，18/39（46%）为乳头状，7/12（58.3%）为滤泡状，3/3（100%）为未分化癌。35/54（64.8%）Galectin-3 阳性病例中，69.2%为乳头状，7/12（58.3%）为滤泡状，3/3（100%）为未分化癌。
沙特阿拉伯北部甲状腺癌较为常见，主要类型为甲状腺乳头状癌。大多数患者为女性且较为年轻。联合使用 CK19、CD56 和 Galectin-3 肿瘤标志物有助于甲状腺肿瘤的准确鉴别诊断。
