Department of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), 1229 Dhaka, Bangladesh.
Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, BT52 1SA Coleraine, UK.
Front Biosci (Schol Ed). 2023 May 5;15(2):5. doi: 10.31083/j.fbs1502005.
Diabetes mellitus (DM), a prevalent non-communicable disease, is a metabolic condition involving defective pancreatic β-cells and/or insulin resistance. Researchers are presently exploring traditional medicinal plants to identify alternatives for treating diabetes due to the various disadvantage of current anti-diabetic medicines.
The present study evaluated the anti-hyperglycaemic effects of ethanol extracts of five medicinal plants (EEMPs) (, , , and ) which are traditionally used as an ethnomedicine to treat diabetes and numerous other health problems.
High-fat fed (HFF) obese rats were used to perform acute tests, including oral glucose tolerance, feeding test, metabolic studies, and gastrointestinal motility using BaSO4 milk solution. Priliminary phytochemical screening were performed to discover the presence or absence of alkaloids, tannins, saponins, steroids, glycosides, flavonoids, and reducing sugars in extracts.
Oral administration of ethanol extracts (250 mg/kg, body weight), along with glucose (18 mmoL/kg body weight), ameliorated glucose tolerance ( < 0.05-0.01). In addition, the extracts improved gut motility (250 mg/kg; < 0.05-0.001), as well as reduced food intake during the feeding test (250 mg/kg; < 0.05-0.001). Phytochemical screening of these medicinal plants depicted the presence of flavonoids, alkaloids, tannins, saponins, steroids and reducing sugars.
Phytochemicals such as flavonoids, tannins and saponins may be responsible for the glucose-lowering properties for these plants. Additional research is warranted to fully identify the bioactive phytomolecules and mechanistic pathways that might lead to the development of a viable, cost-effective type 2 diabetes therapy.
糖尿病（DM）是一种常见的非传染性疾病，是一种涉及缺陷胰腺β细胞和/或胰岛素抵抗的代谢性疾病。由于当前抗糖尿病药物存在各种缺点，研究人员目前正在探索传统药用植物，以寻找治疗糖尿病的替代方法。
本研究评估了五种药用植物（EEMPs）（、、、和）的乙醇提取物的抗高血糖作用，这些植物传统上被用作治疗糖尿病和许多其他健康问题的民族医学。
使用高脂肪喂养（HFF）肥胖大鼠进行急性试验，包括口服葡萄糖耐量、摄食试验、代谢研究以及使用 BaSO4 奶溶液的胃肠道动力。进行初步的植物化学筛选，以发现提取物中是否存在生物碱、单宁、皂苷、类固醇、糖苷、类黄酮和还原糖。
乙醇提取物（250mg/kg，体重）口服给药，同时给予葡萄糖（18mmol/kg 体重），改善了葡萄糖耐量（<0.05-0.01）。此外，提取物改善了肠道动力（250mg/kg；<0.05-0.001），并减少了摄食试验中的食物摄入量（250mg/kg；<0.05-0.001）。这些药用植物的植物化学筛选显示存在类黄酮、生物碱、单宁、皂苷、类固醇和还原糖。
类黄酮、单宁和皂苷等植物化学物质可能是这些植物降低血糖的原因。需要进一步的研究来充分鉴定可能导致开发可行的、具有成本效益的 2 型糖尿病治疗方法的生物活性植物分子和机制途径。
