Pranovich A A, Kalinin D V, Sultanova N O, Stepanova Yu A, Borukaev A Yu
A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.
Urologiia. 2023 May(2):26-31.
Stent encrustation is one of the most difficult problems that can lead to difficulties in stent removal, while ureteral obstruction can lead to renal failure. Despite the search for various preventive measures, it still remains unresolved.
To study the effect of Blemaren on stent encrustation in patients with calcium-containing and uric acid stones after ureteroscopy with lithotripsy.
A total of 60 patients with ureteral stones who underwent ureteroscopy with lithotripsy in A.V. Vishnevsky National Medical Research Center of Surgery from January to August 2022, were included in the study. In all cases ureteral stents 6 Ch were placed at the end of the procedure. Patients with uric acid and calcium oxalate stones (n=48) were randomized into two groups: in the main group (n=20), they were prescribed Blemaren up to the stent removal. In the control group (n=28), patients did not receive additional therapy. To determine the severity of incrustation, we used our own classification, where the percentage of lithogenic deposits relative to the lumen of the stent was calculated. Visual assessment and microscopic examination of the removed stents were performed on days 30+/-4.1 and 60+/-7.3.
In patients of both groups, the severity of encrustation on the 30th day after stent placement was low (up to 30%). There were no significant differences between the groups (p=0.421). The main changes were detected 60 days after stent placement. Microscopic study revealed significant differences between two groups. In patients who did not receive Blemaren, microscopic signs of encrustation of the proximal curl of the stent occurred 2.5 times more often than in the main group (p=0.001).
支架结壳是最棘手的问题之一,可导致支架取出困难,而输尿管梗阻可导致肾衰竭。尽管人们寻求了各种预防措施,但该问题仍未得到解决。
研究Blemaren对输尿管镜碎石术后含钙结石和尿酸结石患者支架结壳的影响。
2022年1月至8月在A.V. 维什涅夫斯基国家外科医学研究中心接受输尿管镜碎石术的60例输尿管结石患者纳入本研究。所有病例均在手术结束时放置6F输尿管支架。尿酸结石和草酸钙结石患者(n = 48)随机分为两组:主要组(n = 20),在支架取出前给予Blemaren治疗。对照组(n = 28),患者未接受额外治疗。为确定结壳的严重程度,我们采用了自己的分类方法,计算结石形成沉积物相对于支架管腔的百分比。在第30±4.1天和第60±7.3天对取出的支架进行视觉评估和显微镜检查。
两组患者在支架置入后第30天结壳严重程度均较低(高达30%)。两组之间无显著差异(p = 0.421)。主要变化在支架置入60天后检测到。显微镜研究显示两组之间存在显著差异。未接受Blemaren治疗的患者中,支架近端卷曲处结壳的微观迹象出现频率比主要组高2.5倍(p = 0.001)。