School of Medicine, Taizhou University, Jiaojiang, China.
Horm Metab Res. 2024 Mar;56(3):193-196. doi: 10.1055/a-2122-5701. Epub 2023 Jul 4.
Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid peroxides and lipid-reactive oxygen species. It is characterized by iron-dependent lipid peroxide accumulation accompanied by oxidoreductase deficiency. Pancreatic beta cell dysfunction and insulin resistance are two major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and metabolism may play a role in the development of T2DM. The molecular mechanism of β cell apoptosis and iron death in T2DM were reviewed. In addition, we discuss recent insights on the relationship between the trace element iron and apoptosis of β cells in T2DM.
铁死亡是一种依赖铁的死亡方式，由脂质过氧化物和脂类活性氧的聚集介导。它的特点是铁依赖性脂质过氧化物积累伴随着氧化还原酶缺乏。胰腺β细胞功能障碍和胰岛素抵抗是 2 型糖尿病（T2DM）的两个主要原因。铁的积累和代谢可能在 T2DM 的发展中起作用。本文综述了 T2DM 中β细胞凋亡和铁死亡的分子机制。此外，我们还讨论了最近关于微量元素铁与 T2DM 中β细胞凋亡关系的新见解。
