Lee J C, Denbow D M, Ashen M D, Roudabush A D
Am J Physiol. 1986 Aug;251(2 Pt 2):R258-63. doi: 10.1152/ajpregu.1986.251.2.R258.
The purpose of this investigation was to examine the possible involvement of the central renin-angiotensin system in the pressor response to the intracerebroventricular (icv) injection of hypertonic NaCl in conscious turkeys. The icv injection was accomplished via a stereotaxically implanted stainless steel guide cannula in the lateral cerebral ventricle. The arterial blood pressure (AP) of the turkey was measured by means of a PE catheter in the left brachial artery. The icv administration of hypertonic NaCl caused a dose-dependent increase of AP. The mean AP increases due to 10-microliter icv injections of 0.9, 3.6, and 7.2% NaCl were 1.4 +/- 1.4, 18.1 +/- 3.0, and 31.2 +/- 3.2 (SE) mmHg, respectively. These changes were statistically significant (P less than 0.001). The icv administration of captopril, [Sar1, Ile8]angiotensin II, or pentobarbital sodium markedly reduced the pressor response to the icv injection of hypertonic 7.2% NaCl. Blockade of central adrenergic receptors with phentolamine and propranolol was without effect. These results support the contention that the central renin-angiotensin system may directly contribute to pressor responses induced by central hypertonic NaCl stimulation.
本研究的目的是检验中枢肾素 - 血管紧张素系统在清醒火鸡对脑室内（icv）注射高渗氯化钠的升压反应中可能的参与情况。通过立体定位植入大脑侧脑室的不锈钢引导套管完成脑室内注射。用置于左肱动脉的PE导管测量火鸡的动脉血压（AP）。脑室内给予高渗氯化钠导致动脉血压呈剂量依赖性升高。由于分别脑室内注射10微升0.9%、3.6%和7.2%的氯化钠，平均动脉血压升高分别为1.4±1.4、18.1±3.0和31.2±3.2（标准误）mmHg。这些变化具有统计学显著性（P<0.001）。脑室内给予卡托普利、[Sar1，Ile8]血管紧张素II或戊巴比妥钠可显著降低对脑室内注射高渗7.2%氯化钠的升压反应。用酚妥拉明和普萘洛尔阻断中枢肾上腺素能受体无效。这些结果支持以下观点，即中枢肾素 - 血管紧张素系统可能直接促成中枢高渗氯化钠刺激诱导的升压反应。
