Koepke J P, Jones S, DiBona G F
Am J Physiol. 1986 Aug;251(2 Pt 2):R289-94. doi: 10.1152/ajpregu.1986.251.2.R289.
The effects of a stressful environmental stimulus (air stress) on mean arterial pressure, heart rate, renal sympathetic nerve activity, and renal function were studied in conscious deoxycorticosterone acetate-sodium chloride (DOCA-NaCl) hypertensive rats, sham DOCA-NaCl normotensive rats, and DOCA-NaCl rats with renal denervation. In conscious DOCA-NaCl hypertensive rats, air stress decreased urine flow rate [36% from 17.9 +/- 3.0 microliter X min-1 X 100 g body wt-1 (BW)], urinary sodium excretion (39% from 3.1 +/- 0.5 microeq X min-1 X 100 g BW-1), fractional water excretion (24% from 4.72 +/- 1.00%), and fractional sodium excretion (28% from 5.72 +/- 1.08%) and increased renal sympathetic nerve activity (94% from 8.3 +/- 0.6 integrator resets/min), but no changes occurred in glomerular filtration rate (-15% from 0.40 +/- 0.06 ml X min-1 X 100 g BW-1) or effective renal plasma flow (-7% from 2.50 +/- 0.53 ml X min-1 X 100 g BW-1). Air stress had no effect on these measures in conscious sham DOCA-NaCl normotensive rats or DOCA-NaCl rats with renal denervation. Mean arterial pressure and heart rate were unaffected by air stress in these three groups. Renal denervation lowered base-line mean arterial pressure in DOCA-NaCl rats. Thus DOCA-NaCl hypertensive rats respond to environmental stress with increased renal sympathetic nerve activity and, consequently, antidiuresis and antinatriuresis.
在清醒的醋酸脱氧皮质酮 - 氯化钠（DOCA - NaCl）高血压大鼠、假手术DOCA - NaCl正常血压大鼠以及去肾神经的DOCA - NaCl大鼠中，研究了应激性环境刺激（空气应激）对平均动脉压、心率、肾交感神经活动和肾功能的影响。在清醒的DOCA - NaCl高血压大鼠中，空气应激使尿流率降低[从17.9±3.0微升×分钟-1×100克体重-1（BW）降低36%]，尿钠排泄降低（从3.1±0.5微当量×分钟-1×100克BW-1降低39%），水排泄分数降低（从4.72±1.00%降低24%），钠排泄分数降低（从5.72±1.08%降低28%），并增加肾交感神经活动（从8.3±0.6积分器重置/分钟增加94%），但肾小球滤过率无变化（从0.40±0.06毫升×分钟-1×100克BW-1降低15%）或有效肾血浆流量无变化（从2.50±0.53毫升×分钟-1×100克BW-1降低7%）。空气应激对清醒的假手术DOCA - NaCl正常血压大鼠或去肾神经的DOCA - NaCl大鼠的这些指标无影响。在这三组中，平均动脉压和心率不受空气应激影响。去肾神经降低了DOCA - NaCl大鼠的基线平均动脉压。因此，DOCA - NaCl高血压大鼠对环境应激的反应是肾交感神经活动增加，从而导致抗利尿和抗利钠作用。
