DiBona G F, Jones S Y
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
J Hypertens. 1995 Jan;13(1):63-8.
To examine whether acute environmental stress (air-jet stress) modulates the exaggerated natriuresis to volume expansion in conscious borderline hypertensive rats.
Intravenous isotonic saline volume expansion was performed with and without superimposed acute air-jet stress in conscious borderline hypertensive rats which had consumed a 1% NaCl diet (normotensive) or an 8% NaCl diet (hypertensive) for 12 weeks.
Conscious rats were instrumented for measurement of arterial pressure, renal sympathetic nerve activity and collection of bladder urine.
Arterial pressure was greater in the 8% NaCl borderline hypertensive rats than in the 1% NaCl borderline hypertensive rats. In the absence of acute air-jet stress the 8% NaCl borderline hypertensive rats exhibited exaggerated natriuresis and exaggerated inhibition of renal sympathetic nerve activity compared with the 1% NaCl borderline hypertensive rats. Acute air-jet stress increased both arterial pressure and renal sympathetic nerve activity reversibly, and attenuated natriuresis in the 8% NaCl but not in the 1% NaCl borderline hypertensive rats.
Acute environmental stress (air-jet stress) attenuates exaggerated natriuresis in hypertensive but not in normotensive borderline hypertensive rats via increased renal sympathetic nerve activity.
研究急性环境应激（喷气应激）是否会调节清醒边缘性高血压大鼠对容量扩张的过度利钠反应。
对食用1%氯化钠饮食（正常血压）或8%氯化钠饮食（高血压）12周的清醒边缘性高血压大鼠，在有或无叠加急性喷气应激的情况下进行静脉输注等渗盐水以扩张血容量。
对清醒大鼠进行仪器植入，以测量动脉血压、肾交感神经活动并收集膀胱尿液。
8%氯化钠饮食的边缘性高血压大鼠的动脉血压高于1%氯化钠饮食的边缘性高血压大鼠。在无急性喷气应激时，与1%氯化钠饮食的边缘性高血压大鼠相比，8%氯化钠饮食的边缘性高血压大鼠表现出过度利钠和对肾交感神经活动的过度抑制。急性喷气应激使动脉血压和肾交感神经活动可逆性增加，并减弱了8%氯化钠饮食但未减弱1%氯化钠饮食的边缘性高血压大鼠的利钠反应。
急性环境应激（喷气应激）通过增加肾交感神经活动减弱高血压边缘性高血压大鼠而非正常血压边缘性高血压大鼠的过度利钠反应。
