University of Lorraine, Laboratory of Stress, Immunity, Pathogens (EA7300), Medical School, 54500 Vandoeuvre-les- Nancy, France.
Dépt Médecine, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-les-Nancy, France.
Curr Rev Clin Exp Pharmacol. 2024;19(2):163-172. doi: 10.2174/2772432819666230703095203.
The 5-HT syndrome in rats is composed of head weaving, body shaking, forepaw treading, flat body posture, hindlimb abduction, and Straub tail. The importance of the brainstem and spinal cord for the syndrome is underlined by findings of 5,7-dihydroxytryptamine (5,7-DHT)-induced denervation supersensitivity in response to 5-HT-stimulant drugs. For head weaving and Straub tail, supersensitivity occurred when the neurotoxin was injected into the cisterna magna or spinal cord, for forepaw treading in cisterna magna, and for hindlimb abduction in the spinal cord. Although 5,7- DHT-related body shaking increased in the spinal cord, the sign decreased when injected into the striatum, indicating the modulatory influence of the basal ganglia. Further details on body shaking are provided by its reduced response to harmaline after 5-HT depletion caused by intraventricular 5,7-DHT, electrolytic lesions of the medial or dorsal raphe, and lesions of the inferior olive caused by systemic injection of 3-acetylpyridine along with those found in or nr cerebellar mouse mutants. Yet the influence of the climbing fiber pathway on other signs of the 5-HT syndrome remains to be determined.
大鼠的 5-HT 综合征由头摆动、身体摇晃、前爪踩踏、平卧位、后肢外展和Straub 尾巴组成。脑干和脊髓对该综合征的重要性突出表现在 5,7-二羟色胺（5,7-DHT）诱导的神经毒剂对 5-HT 兴奋剂药物的反应性去神经超敏现象上。对于头摆动和 Straub 尾巴，当神经毒素注入蛛网膜下腔或脊髓时会出现超敏现象，对于前爪踩踏，则是在蛛网膜下腔注射时出现，而对于后肢外展，则是在脊髓注射时出现。虽然 5,7-DHT 相关的身体摇晃在脊髓中增加，但当注入纹状体时，该症状会减少，这表明基底神经节的调节影响。脑室注射 5,7-DHT 导致 5-HT 耗竭后，对卤丙胺的反应减少，中缝核或背侧缝核的电解损伤，以及系统性注射 3-乙酰吡啶导致的橄榄下核损伤，都进一步详细说明了身体摇晃的情况，这些发现与或 nr 小脑突变鼠的情况一致。然而，攀附纤维通路对 5-HT 综合征的其他症状的影响仍有待确定。
