Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, OK; and.
Department of Ophthalmology and Visual Sciences, University of New Mexico, Albuquerque, NM.
Cornea. 2023 Oct 1;42(10):1301-1305. doi: 10.1097/ICO.0000000000003346. Epub 2023 Jul 4.
The purpose of this study was to describe the management of a case of recurrent scleritis and Acanthamoeba -positive scleral abscess in a patient after the use of miltefosine for recalcitrant Acanthamoeba keratitis.
This is a case study.
In this study, we report a case of advanced Acanthamoeba keratitis with resultant corneal perforation with therapeutic keratoplasty and associated scleritis who later developed a scleral abscess after treatment with oral miltefosine. The scleral abscess was positive for Acanthamoeba cysts and trophozoites, and after treatment for an additional several months, the patient had complete resolution of her disease.
Acanthamoeba scleritis is a rare complication associated with Acanthamoeba keratitis. It has traditionally been treated as an immune reaction and associated inflammation, especially with the use of miltefosine. Management can require a multitude of different approaches, and in this situation, it has been demonstrated that scleritis can be infectious and that conservative management can be effective.
本研究旨在描述一例米替福新治疗难治性棘阿米巴角膜炎后发生复发性巩膜炎和棘阿米巴性巩膜脓肿的病例。
这是一个病例研究。
本研究报告了一例晚期棘阿米巴角膜炎伴角膜穿孔，行治疗性角膜移植术，随后在口服米替福新治疗后发生巩膜炎伴巩膜脓肿。该巩膜脓肿棘阿米巴包囊和滋养体阳性，经额外数月治疗后，患者疾病完全缓解。
棘阿米巴性巩膜炎是棘阿米巴角膜炎的罕见并发症。它传统上被视为免疫反应和相关炎症，尤其是在使用米替福新时。治疗可能需要多种不同的方法，在这种情况下，已经证明巩膜炎可能是感染性的，保守治疗可能是有效的。
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