Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
PeerJ. 2023 Jun 30;11:e15569. doi: 10.7717/peerj.15569. eCollection 2023.
To investigate the effect of cardiac valve calcification (CVC) on the prognosis of patients with chronic kidney disease (CKD).
A total of 343 CKD patients were retrospectively analyzed, and divided into two groups according to the presence or absence of cardiac valve calcification. All patients were followed until death, loss to follow-up, or the end point of the study (December 2021).
The incidence of CVC among the 343 CKD patients was 29.7%, including 21 cases of mitral valve calcification, 63 cases of aortic valve calcification, and 18 cases of mitral valve combined with aortic valve calcification. The incidence of CVC in CKD stages 1-2 was 0.3%, 5.2% in CKD stages 3-4, and 24.2% in CKD stage 5 ( < 0.05). Advanced age, higher serum albumin, higher cystatin C and lower uric acid levels were all associated with a higher risk of CVC. After six years of follow-up, 77 patients (22.4%) died. The causes of death were cardiovascular and cerebrovascular diseases in 36 cases (46.7%), infection in 29 cases (37.7%), gastrointestinal bleeding in nine cases (11.7%), and "other" in the remaining three cases (3.9%). A Kaplan Meier survival analysis showed that the overall survival rate of patients with CVC was lower than that of patients without CVC.
The incidence of CVC, mainly aortic calcification, is high in patients with CKD. Advanced age, higher serum albumin and higher cystatin C levels were associated with a higher risk of CVC. Hyperuricemia was associated with a lower risk of CVC. The overall survival rate of patients with CVC was lower than that of patients without CVC.
探讨心脏瓣膜钙化（CVC）对慢性肾脏病（CKD）患者预后的影响。
回顾性分析 343 例 CKD 患者，根据是否存在心脏瓣膜钙化将其分为两组。所有患者均随访至死亡、失访或研究终点（2021 年 12 月）。
343 例 CKD 患者中 CVC 发生率为 29.7%，其中二尖瓣钙化 21 例，主动脉瓣钙化 63 例，二尖瓣联合主动脉瓣钙化 18 例。CKD 1-2 期 CVC 发生率为 0.3%，CKD 3-4 期为 5.2%，CKD 5 期为 24.2%（<0.05）。高龄、血清白蛋白水平较高、胱抑素 C 水平较高、尿酸水平较低与 CVC 风险增加相关。随访 6 年后，77 例（22.4%）患者死亡。死亡原因分别为心血管疾病 36 例（46.7%）、感染 29 例（37.7%）、胃肠道出血 9 例（11.7%）、“其他”3 例（3.9%）。Kaplan-Meier 生存分析显示，CVC 患者的总体生存率低于无 CVC 患者。
CKD 患者 CVC 发生率较高，以主动脉钙化为主。高龄、血清白蛋白及胱抑素 C 水平较高与 CVC 风险增加相关，高尿酸血症与 CVC 风险降低相关。CVC 患者的总体生存率低于无 CVC 患者。
