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中枢神经系统接触核的遗传结构及其功能意义。

Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus.

机构信息

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.

Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, 221004, China.

出版信息

Neurosci Bull. 2023 Nov;39(11):1638-1654. doi: 10.1007/s12264-023-01084-z. Epub 2023 Jul 5.

DOI:10.1007/s12264-023-01084-z
PMID:37405574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10602992/
Abstract

We previously identified a unique nucleus, the cerebrospinal fluid (CSF)-contacting nucleus. This study aims to understand its gene architecture and preliminarily suggest its functions. The results showed that there were about 19,666 genes in this nucleus, of which 913 were distinct from the dorsal raphe nucleus (non-CSF contacting). The top 40 highly-expressed genes are mainly related to energy metabolism, protein synthesis, transport, secretion, and hydrolysis. The main neurotransmitter is 5-HT. The receptors of 5-HT and GABA are abundant. The channels for Cl, Na, K, and Ca are routinely expressed. The signaling molecules associated with the CaMK, JAK, and MAPK pathways were identified accurately. In particular, the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed. The relationship between the main genes of the nucleus and life activities is preliminarily verified.

摘要

我们之前鉴定了一个独特的核团，即脑脊液（CSF）接触核团。本研究旨在了解其基因结构，并初步推测其功能。结果表明，该核团约有 19666 个基因，其中 913 个与中缝背核（非 CSF 接触）不同。前 40 个高表达基因主要与能量代谢、蛋白质合成、运输、分泌和水解有关。主要神经递质是 5-HT。5-HT 和 GABA 的受体丰富。Cl、Na、K 和 Ca 通道常规表达。与 CaMK、JAK 和 MAPK 途径相关的信号分子被准确识别。特别地，与伤害感受器相关的瞬时受体电位通道和与细胞膜转运相关的溶质载体超家族成员的通道表达显著。该核团的主要基因与生命活动的关系得到初步验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a56/10602992/60353d50a92f/12264_2023_1084_Fig10_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a56/10602992/492c568c3ae6/12264_2023_1084_Fig7_HTML.jpg
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