Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Biomed Pharmacother. 2023 Sep;165:115092. doi: 10.1016/j.biopha.2023.115092. Epub 2023 Jul 4.
Central nervous system (CNS) diseases are the leading cause of death worldwide. By performing compensatory functions and improving the inflammatory microenvironment, the transplantation of neural stem cells (NSCs) can promote functional recovery from brain injury, aging, brain tumours, and other diseases. However, the ability of NSCs to differentiate into neurons is limited, and they are associated with a risk of tumourigenicity. NSC-derived extracellular vesicles (NSC-EVs) can modulate the local microenvironment of the nervous system as well as distant neuronal functions. Thus, cell-free therapy may be a novel remedy for CNS disorders. This article reviews the characteristics, contents, and mechanisms of action of NSC-EVs as well as their roles and application prospects in various CNS diseases.
中枢神经系统（CNS）疾病是全球范围内导致死亡的主要原因。神经干细胞（NSCs）的移植可以通过发挥代偿功能和改善炎症微环境，促进脑损伤、衰老、脑肿瘤等疾病的功能恢复。然而，NSCs 向神经元分化的能力有限，并且存在致瘤风险。NSC 衍生的细胞外囊泡（NSC-EVs）可以调节神经系统的局部微环境以及远处神经元的功能。因此，无细胞治疗可能是 CNS 疾病的一种新疗法。本文综述了 NSC-EVs 的特征、内容、作用机制及其在各种 CNS 疾病中的作用和应用前景。
