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近年来混合抗疟药物发现的合成研究进展。

Recent developments in the synthesis of hybrid antimalarial drug discovery.

机构信息

Department of Chemistry, Ravenshaw University, Cuttack 753003, India.

Department of Chemistry, Ravenshaw University, Cuttack 753003, India.

出版信息

Bioorg Chem. 2023 Oct;139:106706. doi: 10.1016/j.bioorg.2023.106706. Epub 2023 Jun 29.

Abstract

In this 21 century, Malaria remains a global burden and causes massive economic trouble to disease-endemic nations. The control and eradication of malaria is a major challenge that requires an urgent need to develop novel antimalarial drugs. To overcome the aforementioned situation, several researchers have given significant effort to develop hybrid antimalarial agents in the search for new antimalarial drugs. Hence, we have summarized those developments of hybrid antimalarial agents from 2017 to till date. This review illustrates the current progress in the recent synthesis of hybrid antimalarial agents along with focusing on their antimalarial evaluation to find the most potent hybrids. This present mini-review will also be useful for the scientific community for the development of new antimalarial drugs to eradicate malaria.

摘要

在 21 世纪,疟疾仍然是全球负担,给疾病流行国家造成巨大的经济困扰。控制和消除疟疾是一项重大挑战,需要迫切开发新的抗疟药物。为了克服上述情况,一些研究人员为开发杂合抗疟药物做出了重大努力,以寻找新的抗疟药物。因此,我们总结了 2017 年至今杂合抗疟药物的发展情况。本综述说明了近年来杂合抗疟药物合成的最新进展,并重点介绍了它们的抗疟评估,以寻找最有效的杂合物。这篇简短的综述也将有助于科学界开发新的抗疟药物来消除疟疾。

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