Nourinia Ramin, Mashhadi Seyed Mohammadjavad, Abtahi Seyed-Hossein, Nouri Hosein
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Retina Vitreous. 2023 Jul 5;9(1):39. doi: 10.1186/s40942-023-00479-4.
To investigate the association between retinal vein occlusion (RVO) and evidence of previous, unnoticed inner nuclear layer (INL) infarction in the fellow eye.
This prospective case-control study compared the prevalence of INL lesions in the fellow eye of consecutive people with hypertension (PwHTN) with unilateral RVO versus a randomly chosen eye of an age-matched control group of PwHTN without RVO. En face slabs above the outer plexiform layer (OPL) were generated from 6 × 6 fovea-centered optical coherence tomography scans. Cross-sectional scans and en face slabs were surveyed for evidence of active/resolved ischemic INL lesions.
69 PwHTN were included and assigned to two groups, i.e., the RVO group (n = 37; 22 BRVO and 15 CRVO) and the control group (n = 32). There was no inter-group difference regarding age, gender distribution, and background diseases. Resolved INL lesions were more frequent in the RVO group (n = 26) than in the control group (n = 4) (70.3% vs. 12.5%, p < 0.001). BRVO and CRVO cases had similar prevalence of INL lesions in their fellow eyes. Unlike diabetes, ischemic heart disease, and gender, INL lesions were associated with RVO (in the fellow eye) with an odds ratio of 15.7 (95%CI: 4.17-76.73, p < 0.001).
We identified a substantially higher prevalence of INL lesions in PwHTN with RVO compared to PwHTN without RVO. The atrophic appearance of lesions suggests they may serve as early markers of increased RVO risk in individuals with systemic or cardiovascular predisposing factors.
研究视网膜静脉阻塞（RVO）与对侧眼先前未被发现的内核层（INL）梗死证据之间的关联。
这项前瞻性病例对照研究比较了连续性高血压患者（PwHTN）中单侧RVO患者对侧眼与无RVO的年龄匹配的PwHTN对照组随机选择的眼睛中INL病变的患病率。从以黄斑中心凹为中心的6×6光学相干断层扫描中生成外丛状层（OPL）上方的正面平板。对横断面扫描和正面平板进行检查，以寻找活动性/已消退的缺血性INL病变的证据。
纳入69例PwHTN患者，分为两组，即RVO组（n = 37；22例分支静脉阻塞[BRVO]和15例中央静脉阻塞[CRVO]）和对照组（n = 32）。两组在年龄、性别分布和基础疾病方面无差异。RVO组（n = 26）中已消退的INL病变比对照组（n = 4）更常见（70.3%对12.5%，p < 0.001）。BRVO和CRVO病例对侧眼中INL病变的患病率相似。与糖尿病、缺血性心脏病和性别不同，INL病变与（对侧眼的）RVO相关，比值比为15.7（95%置信区间：4.17 - 76.73，p < 0.001）。
我们发现与无RVO的PwHTN相比，有RVO的PwHTN中INL病变的患病率显著更高。病变的萎缩外观表明它们可能是具有全身或心血管易感因素个体中RVO风险增加的早期标志物。
