Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia.
Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, India.
Acta Ophthalmol. 2020 Feb;98(1):e22-e28. doi: 10.1111/aos.14196. Epub 2019 Jul 25.
To study the prevalence of resolved paracentral acute middle maculopathy (PAMM) lesions in fellow eyes of patients with unilateral retinal vein occlusion (RVO) and eyes of healthy individuals.
This case-control observational study took place in a referral university medical centre. Forty-five (17 males, 28 females, 64.7 ± 10.8 years) patients with branch retinal vein occlusion (BRVO), 21 (17 males, 4 females, 68.8 ± 11.2 years) patients with central retinal vein occlusion (CRVO) and 57 healthy individuals (25 males, 32 females, 67.4 ± 10.5 years) were included. Presence of resolved PAMM lesions was evaluated by reviewing cross-sectional scans of 8-mm optical coherence tomography angiography protocol. Resolved PAMM lesion was defined as inner nuclear layer thinning with outer plexiform layer elevation.
Resolved PAMM lesions were found in 32/45 (71.1%) and 15/21 (71.4%) of BRVO and CRVO patients, respectively. In healthy volunteers, resolved PAMM lesions were found in 11/57 (19.3%) individuals with bilateral involvement in 8 individuals (72.7%). RVO patients demonstrated the presence of resolved PAMM lesions in fellow eye significantly more frequently than healthy individuals (odds ratio (OR) 10.6, p < 0.001, 95% CI 4.5-24.6). OR for the presence of large resolved PAMM lesions in BRVO patients and CRVO patients versus healthy individual was 12.1 (p = 0.02, 95% CI 1.5-100.9) and 22.4 (p = 0.005, 95% CI 2.5-200.6), respectively.
Resolved PAMM lesions defined as inner nuclear layer thinning associated with outer plexiform layer elevation are highly prevalent in fellow eyes of patients with unilateral RVO. Resolved PAMM lesions may have an association with RVO.
研究单侧视网膜静脉阻塞（RVO）患者对侧眼和健康个体眼中 resolved paracentral acute middle maculopathy（PAMM）病变的发生率。
本病例对照观察性研究在一家转诊大学医学中心进行。共纳入 45 名（17 名男性，28 名女性，64.7±10.8 岁）分支静脉阻塞（BRVO）患者、21 名（17 名男性，4 名女性，68.8±11.2 岁）中央静脉阻塞（CRVO）患者和 57 名健康个体（25 名男性，32 名女性，67.4±10.5 岁）。通过回顾 8mm 光学相干断层扫描血管造影方案的横截面扫描来评估 resolved PAMM 病变的存在。resolved PAMM 病变定义为内核层变薄伴外丛状层抬高。
BRVO 和 CRVO 患者分别有 32/45（71.1%）和 15/21（71.4%）例发现 resolved PAMM 病变。在健康志愿者中，57 名个体中有 11 名（19.3%）双侧受累，其中 8 名（72.7%）存在 resolved PAMM 病变。RVO 患者对侧眼发生 resolved PAMM 病变的频率明显高于健康个体（比值比（OR）10.6，p<0.001，95%CI 4.5-24.6）。BRVO 患者和 CRVO 患者 resolved PAMM 病变较大的 OR 分别为 12.1（p=0.02，95%CI 1.5-100.9）和 22.4（p=0.005，95%CI 2.5-200.6）。
定义为内核层变薄伴外丛状层抬高的 resolved PAMM 病变在单侧 RVO 患者的对侧眼高度普遍存在。resolved PAMM 病变可能与 RVO 有关。
