Oguchi Y, Morita I, Matsunaga K, Fujii T, Yoshikumi C, Kawai Y, Nomoto K
Gan To Kagaku Ryoho. 1986 Aug;13(8):2645-52.
We examined the effect of PSK on involution of the thymus in tumor-bearing mice. The weight and cell number of the thymus decreased and the size distribution (scatter profile) of thymus cells was changed in X5563-bearing C3H/He mice. Also in these mice, 3H-thymidine incorporation into the thymus was reduced compared with that in control mice, as evaluated not only by per organ but also by per 1 mg of thymus tissue. Such an involution was also observed in tumor-free mice injected with immunosuppressive substance, which had been obtained from ascites of X5563-bearing mice and revealed suppressive activity against lymphocyte proliferation. PSK administration prevented such modulation in the thymus of tumor-bearing mice and immunosuppressive substance-injected tumor-free mice. In other words, it is considered that the various changes in the thymus demonstrated in tumor-bearing mice may be attributable to the suppression of cell proliferation in the thymus, that such suppression is caused at least partly by an immunosuppressive substance which possesses inhibitory activity against lymphocyte proliferation, and that PSK has an antagonistic activity against such a substance so as to restore the function of the thymus in tumor-bearing hosts.
我们研究了PSK对荷瘤小鼠胸腺退化的影响。在携带X5563的C3H/He小鼠中，胸腺的重量和细胞数量减少，胸腺细胞的大小分布（散射图谱）发生改变。同样在这些小鼠中，与对照小鼠相比，不仅按每个器官计算，而且按每1毫克胸腺组织计算，胸腺中3H-胸腺嘧啶核苷的掺入量均减少。在注射了从携带X5563的小鼠腹水中获得的具有淋巴细胞增殖抑制活性的免疫抑制物质的无瘤小鼠中也观察到了这种退化。给予PSK可防止荷瘤小鼠和注射了免疫抑制物质的无瘤小鼠的胸腺出现这种调节变化。换句话说，可以认为荷瘤小鼠胸腺中表现出的各种变化可能归因于胸腺中细胞增殖的抑制，这种抑制至少部分是由对淋巴细胞增殖具有抑制活性的免疫抑制物质引起的，并且PSK对这种物质具有拮抗活性，从而恢复荷瘤宿主胸腺的功能。
