炎症性肠病和前列腺癌风险：两样本孟德尔随机分析。
Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
机构信息
Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
出版信息
Front Immunol. 2023 Jun 20;14:1157313. doi: 10.3389/fimmu.2023.1157313. eCollection 2023.
BACKGROUND
Previous epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) analysis.
METHODS
We performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the Simple Mode, the Weighted Mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.
RESULTS
Genetically determined IBD did not have a causal effect on PCa (IVW > 0.05). Additionally, there was no causal effect of Crohn's disease (CD) and ulcerative colitis (UC) on PCa in the MR analysis (IVW > 0.05). Results of complementary methods were consistent with those of the IVW method.
CONCLUSIONS
This study does not support a causal association of IBD on PCa, which is in contrast to most observational studies.
背景
先前的流行病学观察研究报告称炎症性肠病（IBD）与前列腺癌（PCa）之间存在关联，但因果关系尚无定论。本研究旨在使用孟德尔随机化（MR）分析评估 IBD 对 PCa 的因果关系。
方法
我们使用公开的全基因组关联研究（GWAS）数据进行了两样本 MR 分析。根据 MR 分析的三个假设选择了合格的工具变量（IVs）。主要方法为逆方差加权（IVW）法。补充方法包括 MR-Egger 回归、加权中位数、简单模式、加权模式和 MR 多效性残差和异常值（MR-PRESSO）方法。
结果
遗传确定的 IBD 与 PCa 之间没有因果关系（IVW>0.05）。此外，MR 分析中 CD 和 UC 与 PCa 之间也没有因果关系（IVW>0.05）。补充方法的结果与 IVW 方法一致。
结论
本研究不支持 IBD 与 PCa 之间存在因果关联，这与大多数观察性研究结果相反。
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