Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Protein Pept Lett. 2023;30(8):619-625. doi: 10.2174/0929866530666230705145446.
Orexin (OX, hypocretin: HCRT) as a neuropeptide is produced in a distinct population of neurons in the posterior lateral hypothalamus (LH). OX neurons implicate in reward function. OX makes a main input from the hypothalamus to the ventral tegmental area (VTA) of the midbrain. OX, through OX receptors (OXR1, OXR2) activates VTA dopamine (DA) neurons. VTA neurons are involved in reward processing and motivation. In this review, we will discuss the OX effect on addiction through VTA activation and related areas of the brain.
食欲素（OX，下丘脑泌素：HCRT）作为一种神经肽，在后外侧下丘脑（LH）的特定神经元中产生。OX 神经元与奖赏功能有关。OX 主要从前下丘脑投射到中脑腹侧被盖区（VTA）。OX 通过 OX 受体（OXR1、OXR2）激活 VTA 多巴胺（DA）神经元。VTA 神经元参与奖赏处理和动机。在这篇综述中，我们将讨论通过 VTA 激活和相关脑区探讨 OX 对成瘾的影响。
