耶尔森菌引发的反应性关节炎中的IgA抗耶尔森菌抗体
IgA-anti-yersinia antibodies in yersinia triggered reactive arthritis.
作者信息
Granfors K, Toivanen A
出版信息
Ann Rheum Dis. 1986 Jul;45(7):561-5. doi: 10.1136/ard.45.7.561.
Abstract
Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia antibodies belonging to IgA1, IgA2, or secretory IgA were compared in patients with or without reactive arthritis. In the former group the serum concentration of secretory IgA and of yersinia specific antibodies in all categories studied was raised compared with the level in patients without joint symptoms; the difference was most significant for the IgA-anti-yersinia antibodies with secretory piece or with J chain. The findings suggest that the strong antibody response in the patients developing reactive arthritis is due to a chronic stimulation of the intestinal lymphoid tissue.
摘要
耶尔森氏肠炎后发生反应性关节炎的患者，其特征为IgA抗耶尔森氏菌抗体水平高且持续存在。我们进一步分析了这种情况下对耶尔森氏菌的体液免疫反应。比较了有或没有反应性关节炎的患者血清中IgM、IgG、IgA和分泌型IgA的总浓度以及属于IgA1、IgA2或分泌型IgA的特异性抗耶尔森氏菌抗体。在前一组中，与没有关节症状的患者相比，所有研究类别的分泌型IgA和耶尔森氏菌特异性抗体的血清浓度均升高；对于带有分泌片或J链的IgA抗耶尔森氏菌抗体，差异最为显著。这些发现表明，发生反应性关节炎的患者中强烈的抗体反应是由于肠道淋巴组织的慢性刺激所致。
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