Department of Nanobiochemistry, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 minatojima-Minamimachi, Kobe 650-0047, Japan.
Yaegaki Biotechnology, Inc., 681 Mukudani, Hayashida, Himeji 678-4298, Japan.
ACS Appl Bio Mater. 2023 Jul 17;6(7):2636-2643. doi: 10.1021/acsabm.3c00221. Epub 2023 Jul 6.
Considering recent advances in surgical techniques, sprayable antiadhesion barriers that are compatible with minimally invasive procedures are needed. However, the relatively low mechanical stiffness of the current thixotropic reversible sol-to-gel transition hydrogels has hindered their medical application. Herein, we show a thixotropic sprayable β-chitin nanofiber hydrogel that spontaneously lost the thixotropic property in response to the environments within the living body. Furthermore, interactions between hydrogels and the biological environment result in a significant increase in mechanical stiffness. Due to these advantageous properties, β-chitin nanofiber hydrogels administered by spray prevent postoperative abdominal adhesions and are thus promising sprayable antiadhesion barriers.
考虑到最近外科手术技术的进步，需要与微创手术兼容的可喷涂防粘连屏障。然而，目前的触变可逆溶胶-凝胶转变水凝胶的机械刚度相对较低，这阻碍了它们在医学上的应用。在此，我们展示了一种触变可喷涂的β-壳聚糖纳米纤维水凝胶，它在响应活体内部环境时会自发失去触变性。此外，水凝胶与生物环境的相互作用导致机械刚度显著增加。由于这些有利的特性，通过喷涂给药的β-壳聚糖纳米纤维水凝胶可防止术后腹部粘连，因此是有前途的可喷涂防粘连屏障。
