线粒体质量控制：抗病毒治疗的主要靶点？
Mitochondrial quality control: prime targets for antiviral therapy?
机构信息
School of Medicine, Southern University of Science and Technology, Shenzhen, China.
School of Medicine, Southern University of Science and Technology, Shenzhen, China.
出版信息
Trends Pharmacol Sci. 2023 Oct;44(10):647-650. doi: 10.1016/j.tips.2023.06.006. Epub 2023 Jul 4.
Mitochondrial quality control (MQC) plays a crucial role in maintaining mitochondrial health. Mitochondrial dynamics and mitophagy are two intricate processes of the MQC machinery acting at the organelle level to orchestrate mitochondrial homeostasis. Here, we discuss how viruses perturb these two processes to facilitate their infections and emphasize the rationale and challenges of therapeutically targeting MQC for treating viral diseases.
线粒体质量控制（MQC）在维持线粒体健康方面起着至关重要的作用。线粒体动力学和线粒体自噬是 MQC 机制在细胞器水平上发挥作用以协调线粒体动态平衡的两个复杂过程。在这里，我们讨论了病毒如何扰乱这两个过程以促进其感染，并强调了针对 MQC 进行治疗以治疗病毒疾病的原理和挑战。
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