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Methylglyoxal bis(butylamidinohydrazone), a new inhibitor of polyamine biosynthesis that simultaneously inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase.

作者信息

Hibasami H, Tsukada T, Maekawa S, Nakashima K

出版信息

Biochem Pharmacol. 1986 Sep 1;35(17):2982-3. doi: 10.1016/0006-2952(86)90499-5.

DOI:10.1016/0006-2952(86)90499-5
PMID:3741487
Abstract
摘要

相似文献

1
Methylglyoxal bis(butylamidinohydrazone), a new inhibitor of polyamine biosynthesis that simultaneously inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase.甲基乙二醛双(丁脒腙),一种新型多胺生物合成抑制剂,可同时抑制鸟氨酸脱羧酶、腺苷甲硫氨酸脱羧酶和亚精胺合酶。
Biochem Pharmacol. 1986 Sep 1;35(17):2982-3. doi: 10.1016/0006-2952(86)90499-5.
2
Methylglyoxal bis(cyclohexylamidinohydrazone), a novel inhibitor of polyamine biosynthesis that simultaneously inhibits S-adenosylmethionine decarboxylase and spermidine synthase.甲基乙二醛双(环己基脒腙),一种新型的多胺生物合成抑制剂,可同时抑制S-腺苷甲硫氨酸脱羧酶和亚精胺合酶。
Biochem Pharmacol. 1988 Jan 15;37(2):364-5. doi: 10.1016/0006-2952(88)90744-7.
3
Ornithine decarboxylase and spermidine/spermine N1-acetyltransferase are induced in K562 cells by S-adenosylmethionine decarboxylase inhibitor methylglyoxal bis(guanylhydrazone) but not by analogous methylglyoxal bis(butylamidinohydrazone).在K562细胞中,鸟氨酸脱羧酶和亚精胺/精胺N1 - 乙酰转移酶可被S - 腺苷甲硫氨酸脱羧酶抑制剂甲基乙二醛双(脒基腙)诱导,但不能被类似的甲基乙二醛双(丁基脒腙)诱导。
Biochem Pharmacol. 1986 Nov 15;35(22):4031-5. doi: 10.1016/0006-2952(86)90023-7.
4
Antitumor effect of methylglyoxal bis(3-aminopropylamidinohydrazone), a new inhibitor of S-adenosylmethionine and ornithine decarboxylases, on human erythroid leukemia K562 cells.新型S-腺苷甲硫氨酸和鸟氨酸脱羧酶抑制剂双(3-氨丙基脒腙)甲基乙二醛对人红白血病K562细胞的抗肿瘤作用
Cancer Chemother Pharmacol. 1988;22(3):187-90. doi: 10.1007/BF00273408.
5
Antitumor effect of methylglyoxal bis(butylamidinohydrazone), a new inhibitor of S-adenosylmethionine decarboxylase, against human erythroid leukemia K 562 cells.新型S-腺苷甲硫氨酸脱羧酶抑制剂双脒腙对人红白血病K562细胞的抗肿瘤作用
Cancer Lett. 1986 Jan;30(1):17-23. doi: 10.1016/0304-3835(86)90127-8.
6
Antitumor effect of a new multienzyme inhibitor of polyamine synthetic pathway, methylglyoxal-bis(cyclopentylamidinohydrazone), against human and mouse leukemia cells.多胺合成途径新型多酶抑制剂甲基乙二醛双(环戊基脒腙)对人及小鼠白血病细胞的抗肿瘤作用
Cancer Res. 1989 Apr 15;49(8):2065-8.
7
Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.L-鸟氨酸脱羧酶不可逆抑制后大鼠的卵巢功能
Life Sci. 1980 Dec 8;27(23):2277-83. doi: 10.1016/0024-3205(80)90395-1.
8
[Inhibitors in polyamine biosynthesis (author's transl)].多胺生物合成中的抑制剂(作者译)
Seikagaku. 1981;53(4):255-61.
9
Effects of inhibitors of S-adenosylmethionine decarboxylase and ornithine decarboxylase on DNA synthesis in rat liver after partial hepatectomy.S-腺苷甲硫氨酸脱羧酶和鸟氨酸脱羧酶抑制剂对大鼠部分肝切除术后肝脏DNA合成的影响。
Biochim Biophys Acta. 1978 Jan 26;517(1):169-80. doi: 10.1016/0005-2787(78)90044-8.
10
Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.亚精胺和精胺合成抑制剂对转化小鼠成纤维细胞多胺浓度及生长的影响
Biochem J. 1981 Jan 15;194(1):79-89. doi: 10.1042/bj1940079.