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垂直摆动头部运动引起的间质液切应力降低高血压大鼠和人类的血压。

Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.

机构信息

Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan.

Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

出版信息

Nat Biomed Eng. 2023 Nov;7(11):1350-1373. doi: 10.1038/s41551-023-01061-x. Epub 2023 Jul 6.

DOI:
10.1038/s41551-023-01061-x
PMID:37414976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10651490/
Abstract

The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions mimicking mechanical accelerations experienced during fast walking, light jogging or treadmill running at a moderate velocity reduce the blood pressure of rats and human adults with hypertension. In hypertensive rats, shear stresses of less than 1 Pa resulting from interstitial-fluid flow induced by such passive head motions reduced the expression of the angiotensin II type-1 receptor in astrocytes in the rostral ventrolateral medulla, and the resulting antihypertensive effects were abrogated by hydrogel introduction that inhibited interstitial-fluid movement in the medulla. Our findings suggest that oscillatory mechanical interventions could be used to elicit antihypertensive effects.

摘要

目前，人们尚未完全了解体育锻炼对大脑功能有益的机制。在这里，我们发现，模拟快走、慢跑或在跑步机上以中等速度跑步时所经历的机械加速的垂直摆动头部运动，可降低高血压大鼠和成年高血压患者的血压。在高血压大鼠中，间质液流动引起的小于 1 Pa 的切应力通过这种被动的头部运动减少了延髓腹外侧头端星形胶质细胞中血管紧张素 II 型 1 受体的表达，而水凝胶的引入抑制了延髓间质液的流动，从而消除了由此产生的降压作用。我们的研究结果表明，摆动的机械干预可能被用来引发降压作用。

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