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COVID-19 与血液系统恶性肿瘤:病例系列与文献复习。

COVID-19 in hematological malignancies: Case series and literature review.

机构信息

Department of Haematology and Immunology, University of Nigeria; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Ituku-Ozalla Campus, Enugu, Nigeria.

Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Ituku-Ozalla Campus, Enugu, Nigeria.

出版信息

Ann Afr Med. 2023 Jul-Sep;22(3):381-384. doi: 10.4103/aam.aam_238_21.

Abstract

Earlier reports suggest that cancer patients were twice more likely to contract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this report, we describe two patients with hematological malignancies seen at the peak of the first wave of the coronavirus disease 2019 pandemic. A 61-year-old man was referred to our urology unit he was diagnosed with nodular hyperplasia and multiple myeloma and commenced on bortezomib, thalidomide, and dexamethasone combination chemotherapy. He developed a cough and fever, with SPO 86%, He was positive for SARS-CoV-2 and died a few days later. A 42-year-old man with Hodgkin lymphoma on treatment with Adriamycin, bleomycin, vincristine, and dacarbazine with positive SARS-CoV-2 exposure was diagnosed with pleural effusion at A/E. Three days postadmission, his condition worsened with low SPO despite intranasal oxygen. He died after testing positive for SARS-CoV-2. Patients with hematological malignancies tend to have a greater risk of SARS-COV-2 infection and severe disease due to immunosuppression from cancer and its treatment.

摘要

早期报告表明,癌症患者感染严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的可能性是普通人群的两倍。在本报告中,我们描述了在 2019 年冠状病毒病大流行第一波高峰期间就诊的两名血液系统恶性肿瘤患者。一名 61 岁男性因结节性增生和多发性骨髓瘤被转至我们的泌尿科,随后接受硼替佐米、沙利度胺和地塞米松联合化疗。他出现咳嗽和发热,血氧饱和度(SPO)为 86%,SARS-CoV-2 检测呈阳性,几天后死亡。一名 42 岁男性患有霍奇金淋巴瘤,正在接受阿霉素、博来霉素、长春新碱和达卡巴嗪治疗,有 SARS-CoV-2 暴露史,因胸腔积液被收入急诊。入院后 3 天,尽管接受了鼻内吸氧,他的病情仍恶化,SPO 降低。在 SARS-CoV-2 检测呈阳性后,他死亡。由于癌症及其治疗导致的免疫抑制,血液系统恶性肿瘤患者感染 SARS-CoV-2 和发生重症疾病的风险更高。

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