State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, China.
Beijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.
Adv Exp Med Biol. 2023;1419:127-146. doi: 10.1007/978-981-99-1627-6_10.
Cognitive decline has emerged as one of the greatest health threats of old age. Meanwhile, aging is the primary risk factor for Alzheimer's disease (AD) and other prevalent neurodegenerative disorders. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain aging. Despite playing an important role in the pathogenesis and incidence of disease, brain aging has not been well understood at a molecular level. Recent advances in the biology of aging in model organisms, together with molecular- and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline. This chapter seeks to integrate the knowledge about the neurological mechanisms of age-related cognitive changes that underlie aging.
认知能力下降已成为老年时期最大的健康威胁之一。与此同时，衰老也是阿尔茨海默病（AD）和其他常见神经退行性疾病的主要风险因素。为这些疾病开发治疗干预措施需要更深入地了解正常和病理性大脑衰老的过程。尽管大脑衰老在疾病的发病机制和发病中起着重要作用，但在分子水平上对其了解还不够充分。模式生物衰老生物学的最新进展，以及大脑的分子和系统水平研究，开始揭示这些机制及其在认知能力下降中的潜在作用。本章旨在整合与衰老相关的认知变化的神经机制方面的知识。
