Kühn-Velten N, Bos D, Staib W
Biosci Rep. 1986 May;6(5):451-7. doi: 10.1007/BF01116136.
Evidence is presented that the regulation of the cytochrome P-450(C17 alpha) of the steroid-17 alpha-monooxygenase and of the cytochrome P-450(cscc) of the cholesterol-monooxygenase by human choriogonadotropin (hCG) in vivo is mediated by differential mechanisms in the adult rat testis. An initial down-regulation of the cytochrome P-450(C17 alpha) but not of the P-450(cscc) can be demonstrated. Furthermore, induction of the cytochrome P-450(cscc) requires exposure to higher hCG doses (32% of the maximal induction rate of 43.7 pmol/(testis x d) are achieved with 4IU hCG/single dose) than induction of the P-450(C17 alpha) (59% of the maximal induction rate of 48.4 pmol/(testis x d) with 4IU hCG/single dose). Finally, induction of cytochrome P-450(cscc) starts faster after initiation of hCG treatment than induction of P-450(C17 alpha).
有证据表明，在成年大鼠睾丸中，人绒毛膜促性腺激素（hCG）对甾体17α-单加氧酶的细胞色素P-450（C17α）和胆固醇单加氧酶的细胞色素P-450（cscc）的调节是由不同机制介导的。可以证明，细胞色素P-450（C17α）最初会下调，但细胞色素P-450（cscc）不会。此外，细胞色素P-450（cscc）的诱导比细胞色素P-450（C17α）的诱导需要更高剂量的hCG（单剂量4IU hCG可达到最大诱导率43.7 pmol/（睾丸×天）的32%）（单剂量4IU hCG可达到最大诱导率48.4 pmol/（睾丸×天）的59%）。最后，hCG治疗开始后，细胞色素P-450（cscc）的诱导比P-450（C17α）的诱导更快开始。
