May P B, Mittler J C, Ertel N H
Horm Res. 1979;10(2-3):57-63. doi: 10.1159/000178989.
An intraperitoneal injection of leucine-enkephalin into rats stimulates gonadotropin and prolactin release. To elucidate the mechanism of this releasing property of leucine-enkephalin, rat hemipituitaries were incubated with either enkephalin alone or enkephalin in combination with OHRH. Enkephalin alone had no effect on LH or prolactin release in vitro but potentiated the LH response to LHRH. Neither leucine-enkephalin nor LHRH alone had an effect on GH release; however, when combined, a GH response to LHRH occurred. These results suggest that leucine-enkephalin can modify the pituitary responsiveness to certain hypothalamic releasing hormones by a direct pituitary action.
向大鼠腹腔注射亮氨酸脑啡肽会刺激促性腺激素和催乳素释放。为阐明亮氨酸脑啡肽这种释放特性的机制，将大鼠半垂体分别与单独的脑啡肽或与促性腺激素释放激素（OHRH）联合孵育。单独的脑啡肽对体外促黄体生成素（LH）或催乳素释放无影响，但增强了LH对促黄体生成素释放激素（LHRH）的反应。单独的亮氨酸脑啡肽和LHRH对生长激素（GH）释放均无影响；然而，两者联合时，会出现GH对LHRH的反应。这些结果表明，亮氨酸脑啡肽可通过直接作用于垂体来改变垂体对某些下丘脑释放激素的反应性。
