Department Population Health Sciences, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands.
Department Population Health Sciences, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Environ Int. 2023 Aug;178:108085. doi: 10.1016/j.envint.2023.108085. Epub 2023 Jul 4.
BACKGROUND: Maternal occupational exposure to pesticides has been linked to adverse birth outcomes but associations with residential pesticide exposures are inconclusive. OBJECTIVES: To explore associations between residential exposure to specific pesticides and birth outcomes using individual level exposure and pregnancy/birth data. METHODS: From all 2009-2013 singleton births in the Dutch birth registry, we selected mothers > 16 years old living in non-urban areas, who had complete address history and changed addresses at most once during pregnancy (N = 339,947). We estimated amount (kg) of 139 active ingredients (AI) used within buffers of 50, 100, 250 and 500 m around each mother's home during pregnancy. We used generalized linear models to investigate associations between 12 AIs with evidence of reproductive toxicity and gestational age (GA), birth weight (BW), perinatal mortality, child́s sex, prematurity, low birth weight (LBW), small for gestational age (SGA) and large for gestational age (LGA), adjusting for individual and area-level confounders. For the remainder 127 AIs, we used minimax concave penalty with a stability selection step to identify those that could be related to birth outcomes. RESULTS: Regression analyses showed that maternal residential exposure to fluroxypyr-meptyl was associated with longer GA, glufosinate-ammonium with higher risk of LBW, linuron with higher BW and higher odds of LGA, thiacloprid with lower odds of perinatal mortality and vinclozolin with longer GA. Variable selection analysis revealed that picoxystrobin was associated with higher odds of LGA. We found no evidence of associations with other AIs. Sensitivity and additional analysis supported these results except for thiacloprid. DISCUSSION: In this exploratory study, pregnant women residing near crops where fluroxypyr-meptyl, glufosinate-ammonium, linuron, vinclozolin and picoxystrobin were applied had higher risk for certain potentially adverse birth outcomes. Our findings provide leads for confirmatory investigations on these compounds and/or compounds with similar modes of action.
背景：母体职业性暴露于杀虫剂与不良出生结局有关，但与住宅暴露的相关性尚无定论。
目的：使用个体暴露和妊娠/分娩数据，探讨住宅暴露于特定杀虫剂与出生结局之间的关系。
方法：从荷兰出生登记处 2009-2013 年所有单胎出生中，选择居住在非城市地区、年龄大于 16 岁的母亲，并对其完整的地址历史进行分析，同时妊娠期间母亲的地址最多只发生一次变化（N=339947）。我们估计了妊娠期间每位母亲家周围 50、100、250 和 500 m 缓冲区中 139 种活性成分（AI）的使用量（kg）。我们使用广义线性模型，以个体和区域水平的混杂因素为调整变量，调查了 12 种具有生殖毒性证据的 AI 与胎龄（GA）、出生体重（BW）、围产期死亡率、儿童性别、早产、低出生体重（LBW）、小于胎龄（SGA）和大于胎龄（LGA）之间的关系。对于其余 127 种 AI，我们使用最小极大凹惩罚和稳定性选择步骤来确定与出生结局相关的 AI。
结果：回归分析表明，母体住宅暴露于氟氧吡啶甲酯与 GA 延长有关，草铵膦与 LBW 风险增加有关，利谷隆与 BW 升高和 LGA 风险增加有关，噻虫啉与围产期死亡率降低有关，戊唑醇与 GA 延长有关。变量选择分析显示，肟菌酯与 LGA 风险增加有关。我们没有发现其他 AI 与这些结局之间存在关联的证据。敏感性和额外的分析支持了这些结果，除了噻虫啉。
讨论：在这项探索性研究中，居住在施用氟氧吡啶甲酯、草铵膦、利谷隆、戊唑醇和肟菌酯的作物附近的孕妇，其某些潜在不良出生结局的风险更高。我们的研究结果为这些化合物和/或具有类似作用模式的化合物的验证性研究提供了线索。
Res Rep Health Eff Inst. 2016-9
Environ Sci Pollut Res Int. 2023-3
J Med Assoc Thai. 2015-5
J Epidemiol Community Health. 2008-8
Sci Total Environ. 2017-10-17
Am J Ind Med. 1992
Research (Wash D C). 2025-6-25
Environ Health Perspect. 2024-9
Zotero 插件