Seidler F J, Slotkin T A
Brain Res. 1986 Aug;393(2):274-7. doi: 10.1016/0165-3806(86)90031-3.
When subjected to stress, neonatal rats secrete adrenal catecholamines by a mechanism which does not require nerve stimulation. To test whether the non-neurogenic secretory mechanism involves exocytosis, we examined the effects of hypoxia (a non-neurogenic stimulus) and nicotine (a stimulus which simulates neurogenic input) on catecholamine levels and on the uptake of [3H]epinephrine into chromaffin granules. Hypoxia- and nicotine-induced depletion of catecholamines were both accompanied by a reduction in uptake, indicating a loss of granule integrity which is characteristic of exocytosis. Although a significant proportion of adrenal catecholamines was found to be extragranular, only the granular pool was involved in the secretory response.
新生大鼠在受到应激时，会通过一种不需要神经刺激的机制分泌肾上腺儿茶酚胺。为了测试非神经源性分泌机制是否涉及胞吐作用，我们研究了缺氧（一种非神经源性刺激）和尼古丁（一种模拟神经源性输入的刺激）对儿茶酚胺水平以及[3H]肾上腺素摄取到嗜铬颗粒中的影响。缺氧和尼古丁诱导的儿茶酚胺耗竭均伴有摄取减少，表明颗粒完整性丧失，这是胞吐作用的特征。尽管发现相当一部分肾上腺儿茶酚胺存在于颗粒外，但只有颗粒池参与了分泌反应。
