Nykode Therapeutics ASA, Oslo Science Park, Gaustadalléen 21, 0349 Oslo, Norway.
Microbiol Res. 2023 Oct;275:127446. doi: 10.1016/j.micres.2023.127446. Epub 2023 Jul 5.
Historically, Klebsiella pneumoniae isolates were described either as hypervirulent or classical. While hypervirulent strains display a precise phenotype (thicker capsule, hypermucoviscosity, absence of antibiotic resistance markers, several siderophores, etc.), classical strains can relate to all other K. pneumoniae strains, including virulent multidrug-resistant clinical isolates. Recently, many surveillance studies reported virulent K. pneumoniae nosocomial strains resistant to all antibiotic classes which also contain genetic markers associated with hypervirulence. Due to their higher virulence and clinical importance, here it is proposed reclassify them as ultravirulent and as supervirulent, to distinguish them from each other and from those with either hypervirulent or virulent phenotypes.
从历史上看，肺炎克雷伯菌的分离株被描述为高毒力或经典型。虽然高毒力菌株表现出精确的表型（较厚的荚膜、高度黏液性、缺乏抗生素耐药标志物、几种铁载体等），但经典菌株可能与所有其他肺炎克雷伯菌菌株有关，包括毒力多药耐药的临床分离株。最近，许多监测研究报告称，具有高毒力的医院获得性肺炎克雷伯菌菌株对所有抗生素类别均具有耐药性，同时还含有与高毒力相关的遗传标志物。由于其更高的毒力和临床重要性，因此建议将它们重新分类为超强毒力和超级毒力，以将它们彼此区分开来，并与具有高毒力或毒力表型的菌株区分开来。
