Department of Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.
Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France.
Nephron. 2024;148(2):74-77. doi: 10.1159/000531314. Epub 2023 Jul 7.
The new European Kidney Function Consortium (EKFC) creatinine-based equation has been developed to be applicable over the entire age range (from 2 to 100 years) without any loss of performance in young adults and without loss of continuity in estimating glomerular filtration rate (GFR) between adolescents and adults. This goal is obtained by better taking into account the relationship between serum creatinine (SCr) and age in the estimating GFR model. This is accomplished by rescaling SCr, namely, dividing SCr by so-called Q value which is the median normal value of SCr concentration in a given healthy population. The better performance of the EKFC equation, compared to the current equations, has been shown in large European and African cohorts. Such good results are also suggested in cohorts from China, including in the current issue of Nephron. The good performance of the EKFC equation is observed, especially when the authors used a specific Q value for their populations notwithstanding GFR was measured by a controversial method. Using a population-specific Q value could make the EFKC equation universally applicable.
新的欧洲肾脏功能联盟（EKFC）基于肌酐的公式已被开发出来，可适用于整个年龄段（2 至 100 岁），在年轻人中不会降低性能，并且在青少年和成年人之间估计肾小球滤过率（GFR）时不会失去连续性。通过在估计 GFR 模型中更好地考虑血清肌酐（SCr）与年龄之间的关系来实现这一目标。这是通过对 SCr 进行重新缩放来实现的，即，将 SCr 除以所谓的 Q 值，Q 值是给定健康人群中 SCr 浓度的中位数正常值。与当前方程相比，EKFC 方程在大型欧洲和非洲队列中表现出更好的性能。在中国的队列中也有这样的良好结果，包括本期《肾单位》。作者指出，即使使用有争议的方法测量 GFR，EKFC 方程也表现出良好的性能，特别是当作者为其人群使用特定的 Q 值时。使用特定于人群的 Q 值可以使 EFKC 方程具有普遍适用性。
