Olson L D
Can J Vet Res. 1986 Jul;50(3):365-8.
Swine dysentery did not recur during a nine week period after withdrawal of medication in swine fed ronidazole at a level of 60 parts per million of feed for ten weeks or fed either carbadox at 55 ppm or lincomycin at 110 ppm of feed for six weeks. During this period swine dysentery was neither transmitted to accompanying sentinels after the withdrawal of the above medication or was Treponema hyodysenteriae isolated and cultured or observed in stained smears from rectal swabs and feces or from colonic scrapings at necropsy. Beginning three weeks after the withdrawal of medication, all swine were fed sodium arsanilate at a concentration of 220 ppm of feed for three weeks in an attempt to excite the carrier of swine dysentery into developing a swine dysentery diarrhea. A swine dysentery diarrhea did recur during the feeding of sodium arsanilate in swine previously fed ronidazole at a level of 60 ppm of feed for only six weeks. It was concluded: that swine dysentery was probably eliminated with the feeding of ronidazole for the longer duration and with the feeding of carbadox and lincomycin and that sodium arsanilate was of value in identifying the carrier state.
在以百万分之60的水平在饲料中添加罗硝唑喂养猪10周,或以百万分之55的水平添加卡巴氧或百万分之110的水平添加林可霉素喂养猪6周后停药的9周期间,猪痢疾未复发。在此期间,在停用上述药物后,猪痢疾既未传染给同栏的哨兵猪,也未从直肠拭子、粪便或尸检时的结肠刮片中分离培养或在染色涂片上观察到猪痢疾密螺旋体。在停药3周后,为了激发猪痢疾带菌者出现猪痢疾性腹泻,所有猪以百万分之220的浓度在饲料中添加对氨基苯胂酸钠喂养3周。在之前仅以百万分之60的水平在饲料中添加罗硝唑喂养6周的猪中,在添加对氨基苯胂酸钠喂养期间确实再次出现了猪痢疾性腹泻。得出的结论是:猪痢疾可能通过较长时间喂养罗硝唑以及喂养卡巴氧和林可霉素而被消除,并且对氨基苯胂酸钠在识别带菌状态方面具有价值。