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腹泻对摄入蛋白质和脯氨酸浓度不同日粮的仔猪体内14C-苯丙氨酸氧化的影响。

The effect of diarrhea on the oxidation of 14C-phenylalanine in piglets receiving diets varying in protein and proline concentration.

作者信息

Ball R O, Bayley H S

出版信息

Can J Vet Res. 1986 Jul;50(3):393-6.

PMID:3742376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1255233/
Abstract

The oxidation rate of L-[1-14C]phenylalanine in piglets suffering from diarrhea and receiving diets varying in concentration of protein or proline was compared to the oxidation rates in healthy animals. Phenylalanine oxidation was used to indicate the partition of absorbed amino acids between protein synthesis and oxidation. Piglets receiving adequate protein diets and suffering from diarrhea oxidized significantly more phenylalanine (P less than 0.001) than healthy piglets. Piglets receiving additional proline and with symptoms of diarrhea oxidized phenylalanine at rates 50 to 70% higher than healthy piglets. The results show that piglets with diarrhea are less able to retain absorbed amino acids for protein synthesis than healthy pigs. The reduced nitrogen retention commonly observed in animals with diarrhea may be partly explained by the increased catabolism of absorbed amino acids.

摘要

将患腹泻且摄入蛋白质或脯氨酸浓度不同日粮的仔猪中L-[1-¹⁴C]苯丙氨酸的氧化率与健康动物的氧化率进行比较。苯丙氨酸氧化用于表明吸收的氨基酸在蛋白质合成和氧化之间的分配情况。摄入充足蛋白质日粮且患腹泻的仔猪比健康仔猪氧化的苯丙氨酸显著更多(P<0.001)。摄入额外脯氨酸且有腹泻症状的仔猪氧化苯丙氨酸的速率比健康仔猪高50%至70%。结果表明,与健康猪相比,患腹泻的仔猪将吸收的氨基酸保留用于蛋白质合成的能力较弱。腹泻动物中常见的氮保留减少可能部分是由于吸收的氨基酸分解代谢增加所致。

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本文引用的文献

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Hormonal regulation of protein degradation and synthesis in skeletal muscle.骨骼肌中蛋白质降解与合成的激素调节。
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Plasma aminogram in pigs with infectious Escherichia coli diarrhea.感染性大肠杆菌腹泻猪的血浆氨基酸谱
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Time course of the total and radioactive carbon dioxide production by piglets receiving dietary [14C]phenylalanine.摄入含[14C]苯丙氨酸日粮的仔猪产生总二氧化碳和放射性二氧化碳的时间进程。
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Proline as an essential amino acid for the young pig.
Br J Nutr. 1986 May;55(3):659-68. doi: 10.1079/bjn19860072.
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Influence of dietary protein concentration on the oxidation of phenylalanine by the young pig.
Br J Nutr. 1986 May;55(3):651-8. doi: 10.1079/bjn19860071.